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2.
J Pediatr Gastroenterol Nutr ; 5(3): 492-500, 1986.
Article in English | MEDLINE | ID: mdl-3723274

ABSTRACT

Neonatal hepatitis is a nonspecific term that may include a variety of disease entities. Two patients are presented who developed jaundice in the neonatal period and progressive hepatosplenomegaly. The infants were initially felt to have "neonatal hepatitis" but were subsequently found to have Niemann-Pick disease. Biochemical investigation revealed normal levels of sphingomyelinase activity in leukocytes and liver but diminished levels in cultured skin fibroblasts, compatible with Niemann-Pick type C.


Subject(s)
Hepatitis/diagnosis , Niemann-Pick Diseases/diagnosis , Diagnosis, Differential , Humans , Infant, Newborn , Male
3.
J Clin Gastroenterol ; 8(2): 177-80, 1986 Apr.
Article in English | MEDLINE | ID: mdl-3745853

ABSTRACT

Celiac sprue usually results in biochemical and clinical signs of malabsorption, nutrient loss, and resulting growth failure. We report a child with celiac sprue diagnosed at 1 year of age who was initially cachectic but who eventually developed obesity while taking a gluten-containing diet.


Subject(s)
Celiac Disease/complications , Obesity/etiology , Celiac Disease/diet therapy , Female , Glutens/therapeutic use , Humans , Infant , Male
4.
J Pediatr ; 106(2): 311-6, 1985 Feb.
Article in English | MEDLINE | ID: mdl-3968623

ABSTRACT

We evaluated the effect of domperidone, a novel prokinetic agent, on symptoms and esophageal and gastric motility in 15 infants (six boys), mean age 7.9 months, with moderate to severe gastroesophageal reflux (GER) and upper gastrointestinal motility disturbances. Patients received domperidone orally for 6 weeks and underwent weekly assessment of five GER-associated symptoms, weight change, and side effects. Mean total symptom scores significantly improved after treatment (P less than 0.01). Vomiting, "spitting," and coughing each improved significantly. Postprandial reflux time (defined as esophageal pH less than 4.0) and percent peristaltic esophageal contractions improved significantly (p less than 0.05). Gastric fundic contractions, present in only four infants before treatment, occurred in nine after domperidone administration. Although mean gastric emptying of isotope-labeled formula was not improved, it improved greater than or equal to 10% over baseline in nine patients. Peristaltic amplitude, lower esophageal sphincter pressure, and esophageal acid clearance time were unchanged. Side effects were minimal. We conclude that domperidone is a useful and safe agent for treatment of gastroesophageal reflex in infants because it addresses the motility abnormalities inherent in the pathophysiology of the disorder.


Subject(s)
Domperidone/therapeutic use , Gastroesophageal Reflux/physiopathology , Gastrointestinal Motility/drug effects , Domperidone/adverse effects , Drug Administration Schedule , Esophagus/physiopathology , Female , Follow-Up Studies , Gastric Emptying/drug effects , Gastroesophageal Reflux/drug therapy , Humans , Infant , Male , Peristalsis/drug effects
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