[The efficacy of using low doses of immunomodulators for treating experimental tumors]. / Effektivnost' primeneniia malykh doz immunomoduliatorov dlia lecheniia éksperimental'nykh opukholei.

The data about the ability of various substances to cause definite reactions in biological objects are adduced, and, in particular, about the efficacy of a small doses of antitumoral chemopreparations in experiment. The results of investigation of the application efficacy of various doses of immunomodulating agents, such as arbisol, nucleoplat, the substrate from gram-negative bacteria Yersinia enterocolitica, antitumoral vaccine from the tumoral cells are presented for the cancer chemotherapy. While application of super-small doses of an antitumoral vaccine there was noted statistically significant inhibition of tumoral growth.

[The immunocorrection with Aerosil-350 of the natural resistance of mice found under conditions of an elevated radiation background]. / Immunokorrektsiia aérosilom-350 estestvennoi rezistentnosti myshei, nakhodivshikhsia v usloviiakh povyshennogo radiatsionogo fona.

Experiments on the CBA mice that had been within 30 km of the Chernobyl NPP accident for 3 months revealed a decrease in the phagocytic and bactericidal properties of peritoneal macrophages accompanied with a disturbance in the production of interleukin-1 and a tumor necrosis factor responsible for the cell immunity. A single administration of a silicon-containing enterosorbent Aerosil-350 expedient to remove radionuclides and ensure the organism detoxication made it possible to correct and restore the affected cell and organism immunity for 7 days.

[Antibodies to Bacillus megaterium H glycoprotein in patients with lung diseases]. / Antitela k glikoproteinu Bacillus megaterium H u bol'nykh s legochnoi patologii.

Enzyme immunoassay performed in patients with malignant and benign affections of the lungs determined antibodies (Abs) to glycoprotein isolated from saprophyte microorganism Bacilus megaterium H. In pulmonary tuberculosis and nonspecific pulmonary inflammation the above Abs occurred in patients with fibrous-proliferative changes and associated neoplastic conditions. In lung cancer the Abs were detected in well and moderately differentiated tumors. Nondifferentiated and poorly differentiated variants did not exhibit any rise in Abs to glycoprotein.

[Determination of antibodies to cross-reacting antigens of microorganisms in oncological diseases]. / Opredelenie antitel k perekrestno reagiruiushchim antigenam mikroorganizmov pri onkologicheskikh zabolevaniiakh.

It was studied antibodies to saprophytic microorganism Bacillus megaterium H glycoprotein in healthy, oncological, non-oncological gastrointestinal patients and animals. High level of antibodies to microbial glycoprotein in blood sera was revealed in cancer and precancer patients. Analogical results were obtained in mice A/Sn and Balb/c with inductive or transplanted tumors. It has been suggested the use of Bacillus megaterium H glycoprotein (M. m. 65-70 kD) for immunological monitoring.

[Change in the activity of tumor cell antigens as affected by treatment of the cells with the metabolic products of Bac. mesentericus AB-56]. / Izmenenie aktivnosti antigenov kletok opukholei pri obrabotke ikh produktami metabolizma Bac. mesentericus AB-56.

Tumour cells (ascitic A/Sn mouse lymphosarcoma ON-2), treated by the Bac. mesentericus AB-56 metabolism products used for the production of antitumour autovaccines were analyzed for their antigenic properties. The reactions of precipitation in gel, zonal and oncoming immunoelectrophoresis, passive hemagglutination as well as cytotoxic, absorption and transplantation tests were used. A considerable number of soluble and insoluble antigens inherent in intact tumour cells were inactivated by the products of microbial metabolism in the process of antitumour vaccine production, and modified antigens which induce synthesis of humoral antibodies in the syngenic system appeared.