ABSTRACT
The antiviral effect of 2',5'-trioligoadenylate (2',5'-A3) and some of its analogues was studied using several model cell culture systems and viruses: mice L929 fibroblast cells inoculated with vaccine virus, testicular piglet cells inoculated with Aueszki disease virus (strain BUK-628), and the same culture inoculated with a reference strain of transmissible gastroenteritis virus, strain Purdue-115. Our results suggest that both 2',5'-trioligoadenylate and its analogues are promising antiviral substances against DNA- and RNA-containing viruses.
Subject(s)
Adenine Nucleotides/pharmacology , Antiviral Agents/pharmacology , Herpesvirus 1, Suid/drug effects , Oligoribonucleotides/pharmacology , Transmissible gastroenteritis virus/drug effects , Vaccinia virus/drug effects , Animals , Cells, Cultured/virology , Fibroblasts/virology , Mice , Microbial Sensitivity Tests , Swine/virologyABSTRACT
The effect of trimeric 2',5'-oligoadenylic acid (2',5' A3) and its epoxy-derivative (2',5'-A2 (RAA) on human immunodeficiency virus (HIV-1) reproduction was studied. An HIV-1 infectivity titer decrease was shown on the model of limphoblastoid cells when the substances under study were used. The interferonogenic effect of both substances was discovered. 2',5'-A2 (RAA) inhibited the activity of retrovirus reverse transcriptase (a C-type).
