[Algorithm of cardiopulmonary resuscitation in a cardiological hospital]. / Algoritm serdechno-legochnoi reanimatsii v statsionare kardiologicheskogo profilia.

Recent comments and amendments to routine algorithm of P. Safar's cardiopulmonary resuscitation, known as the ABCD principle, are critically analyzed. The primary mechanisms of thanatogenesis in sudden death in the majority of cases are not respiratory problems (requiring ABCD algorithm), but cardiac rhythm disorders. Based on their studies and practical and training experience, the authors suggest a new algorithm of cardiopulmonary resuscitation: UNIVERSAL, with the following steps: precordial stroke, indirect massage of the heart, forced ventilation of the lungs, venipuncture, electrocardiography, defibrillation by electric pulse therapy, electrocardiostimulation, and injections of adrenalin, atropine, and lidocaine. Introduction of this algorithm decreased hospital mortality of acute coronary patients, increased the rate of reanimation of suddenly dead patients, and reduced the incidence of iatrogenic complications of resuscitation.

[Mechanisms of the optimization of oxygen metabolism under the effects of mafusol and mildronate during emergency implantation of hip prosthesis]. / Mekhanizmy optimizatsii kislorodnogo biudzheta organizma pod vliianiem mafusola i mildronata pri ékstrennom éndoprotezirovanii tazobedrennogo sustava.

The results of using antihypoxants Mafusol and Mildronate in the course of emergency endoprosthesis of the hip joint were analyzed in 41 patients at the age of (80.5 +/- 5.6) years with fractures of the proximal part of the femoral bone. The authors noted optimization of the organism oxygen budget under the influence of the drugs, its physiological mechanisms being deciphered. The protective properties of these drugs manifested themselves in lower consumption of oxygen by the tissues with greater possibilities of its release by oxyhemoglobin as well as in the lessening of intrapulmonary shunting and prevention of the development of metabolic acidosis.

[Use of antihypoxants in the acute period of myocardial infarction]. / Primenenie antigipoksantov v ostrom periode infarkta miokarda.

A total of 620 patients with acute myocardial infarction were followed up in order to assess the efficacy of antihypoxants as a component of intensive care. 385 of these patients, divided into groups of 20-40 subjects, were administered one of 12 antihypoxants or sessions of hyperbaric oxygenation during the acute period of the disease, the rest were treated traditionally. Analysis of clinical, laboratory, and prognostic values showed the highest protective effect of amtizol, lithium hydroxybutyrate, piracetam, and ubiquinone. Cytochrome C, riboxine, mildronate, and olifen were somewhat less active, and solcoseryl, bemitil, trimethasidine, and aspisol were the least effective. The protective potentialities of standard sessions of hyperbaric oxygenation were virtually null. The author proposes a parameter D, reflecting the difference between actual and predicted mortality, and the rating (score) system for assessing the routine laboratory diagnostic tests to be used together with the known criteria for evaluation of the protective effects of antihypoxants in patients with acute myocardial infarction.

[Standards of examination, anesthesia and postoperative care of surgical patients with concomitant cardiovascular diseases]. / Standarty obsledovaniia, anestezii i posleoperatsionnogo vedeniia khirurgicheskikh bol'nykh s soputstvuiushchei serdechno-sosudistoi patologiei.

The authors present the standards for postoperative care of patients with concomitant cardiovascular diseases used at Medical Center No. 122 in St. Petersburg. Special attention is paid to detailed assessment of cardiac function, continuity of the pre-, intra-, and postoperative cardio- and vasotropic therapy, and adequacy of anesthesiological protection as the main guarantee of an uneventful postoperative course. The authors consider it important that preoperative examinations include echocardiography and daily ECG monitoring; preoperative treatment is to include antibiotic prevention of infective endocarditis and heparin prevention of pulmonary artery embolism in the risk group patients. Alternative methods for intraoperative hemodynamic monitoring are pulmonary artery catheterization and integral rheography with the real-time data processing. The importance of regional anesthesia and the hazards of hypercorrection of the globular volume are emphasized.

[Effect of gutimine derivatives on the metamorphosis of Rana temporaria tadpoles]. / O vliianii proizvodnykh gutiminovogo riada na metamorfoz golovastikov Rana temporaria.

A one-time addition of gutimine (0.5 g/l), amtizol (0.2 g/l), and unithiol (0.25 g/l) to the medium at early stages of tadpole development was shown to inhibit metamorphosis only upon addition of unithiol. Repeated addition of gutimine, amtizol, and unithiol to the medium leads to reliable delay in metamorphosis. The delay is more pronounced at addition of the compounds to the medium at late stages of tadpole development (beginning at 40 stage). This suggests that the studied compounds may have anti-thyroid activity. All drugs under study induce the skin clearing.