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1.
Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats.
Sempinska, E; Kostka, B; Królikowska, M; Kalisiak, E.
Pol J Pharmacol Pharm ; 29(1): 7-10, 1977.
Article in English | MEDLINE | ID: mdl-854480

ABSTRACT

Decrease of the platelet adhesiveness in rats by some flavonoids has been stated using the method of glass wool filter. The antiadhesive activity of investigated flavonoids may be ordered as follows: nobiletin greater than isorhamnetin 5,7,4'-trimethylether 3-glucoside greater than isorhamnetin 3-glucoside. Methylation of hydroxyl groups of isorhamnetin-3-glucoside markedly increases its antiadhesive activity.


Subject(s)
Flavonoids/pharmacology , Platelet Adhesiveness/drug effects , Animals , Depression, Chemical , Female , In Vitro Techniques , Methylation , Rats , Structure-Activity Relationship
2.
Spontaneously increased platelet adhesiveness in multiparous rats--a model for the evaluation of antithrombogenic drugs.
Sempinska, E; Kostka, B; Sliwinska, H.
Acta Med Pol ; 17(4): 255-60, 1976.
Article in English | MEDLINE | ID: mdl-1016516

Subject(s)
Antithrombins/therapeutic use , Flavonoids/therapeutic use , Platelet Adhesiveness , Pregnancy , Animals , Disease Models, Animal , Drug Evaluation, Preclinical , Female , Rats
3.
Hyaluronidase activity in serum of patients with complicated atherosclerosis.
Sempinska, E; Kielbasinska, E; Kostka, B; Mazurowa, A.
Acta Med Pol ; 17(1): 79-84, 1976.
Article in English | MEDLINE | ID: mdl-1258694

Subject(s)
Arteriosclerosis/enzymology , Hyaluronoglucosaminidase/blood , Adolescent , Adult , Age Factors , Aged , Arteriosclerosis/blood , Child , Female , Humans , Male , Middle Aged
4.
Radiation-induced chromatid aberrations in the bone marrow and lymph nodes of the rat during the first 24 h after irradiation.
Sempinska, E.
Mutat Res ; 17(1): 121-6, 1973 Jan.
Article in English | MEDLINE | ID: mdl-4682597

Subject(s)
Bone Marrow Cells , Bone Marrow/radiation effects , Chromatids/radiation effects , Chromosome Aberrations , Lymph Nodes/radiation effects , Radiation Effects , Animals , Autoradiography , Female , Male , Mitosis/radiation effects , Rats , Thymidine/metabolism , Time Factors , Tritium
5.
The fate of heterologous DNA microinjected into eggs of amphibians during their development. II. Investigations by centrifugal chromatography on DEAE-cellulose paper pulp, ultracentrifugation in CsCl gradient and DNA-DNA hybridization in agar gel.
Sempinska, E; Ledoux, L.
Biochim Biophys Acta ; 138(3): 570-86, 1967 May 30.
Article in English | MEDLINE | ID: mdl-5341203

Subject(s)
Cell Division , DNA, Bacterial/metabolism , Ovum/metabolism , Amphibians/embryology , Animals , Cellulose , Centrifugation, Density Gradient , Chromatography , Escherichia coli , Female , Gels , Hybridization, Genetic , Injections , Thymine/metabolism , Tritium , Ultracentrifugation
6.
[The fate and the effects of heterologous DNA injected into the eggs of Batracia during development. I. Cytologic and autoradiographic studies]. / Le sort et les effets de DNA hétérologue injecté dans des oeufs de Batraciens en cours de développement. I. Etudes cytologiques et autoradiographiques.
Sempinska, E.
Exp Cell Res ; 45(1): 148-57, 1967 Jan.
Article in French | MEDLINE | ID: mdl-5336839

Subject(s)
DNA, Bacterial/metabolism , DNA/metabolism , Thymus Gland/enzymology , Animals , Autoradiography , Cell Division , Cell Membrane/metabolism , Cell Nucleus/metabolism , Cytoplasm/metabolism , Escherichia coli , Histones/metabolism , Tritium , Urodela/embryology
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