ABSTRACT
Fifteen eyes of nine infants were treated for retinopathy of prematurity by confluent photocoagulation of the avascular retina using an argon laser indirect ophthalmoscope. All treated eyes presented at or beyond threshold of stage 3 retinopathy of prematurity with "plus" disease. Three treated eyes had retinopathy of prematurity in zone I. Early complete regression of extraretinal proliferation was seen in 13 eyes. At 6 month's [corrected] minimum follow-up, 11 (73%) of the treated eyes demonstrated a favorable outcome, while four eyes (27%) progressed to an unfavorable outcome. No intraocular hemorrhages occurred during any laser treatment.
Subject(s)
Light Coagulation , Retinopathy of Prematurity/surgery , Cryosurgery , Follow-Up Studies , Fundus Oculi , Humans , Infant , Infant, Newborn , Postoperative Complications , Retinal Hemorrhage/surgery , Treatment Outcome , Vitreous Hemorrhage/surgerySubject(s)
Laser Therapy , Light Coagulation , Retinopathy of Prematurity/surgery , Cryosurgery , Humans , Infant, Newborn , Laser Therapy/instrumentation , Laser Therapy/methods , Ophthalmoscopes , Postoperative Period , Retinopathy of Prematurity/complications , Retinopathy of Prematurity/pathology , Vitreous Hemorrhage/complicationsSubject(s)
Arthritis, Juvenile/complications , Neovascularization, Pathologic , Optic Disk/blood supply , Cataract/complications , Cataract Extraction , Child, Preschool , Female , Fluorescein Angiography , Fundus Oculi , Humans , Optic Disk/drug effects , Triamcinolone Acetonide/therapeutic use , Visual AcuityABSTRACT
The pigment dispersion syndrome is associated with a secondary open-angle glaucoma most commonly found in young, myopic, white males. We studied 20 cases (38 eyes) of pigment dispersion syndrome in black individuals as defined by heavy deposition on the corneal endothelium and trabecular meshwork with increased intraocular pressure but no other ocular abnormalities. The 20 patients were a homogeneous group that was typified by older age distribution (average, 73 years), a preponderance of hyperopia (median refraction, +2.15 diopters spherical equivalent), female gender (19 women, one man), no iris transillumination defects (zero of 38 eyes), and flatter iris insertion into the ciliary body. We believe that this homogeneous group of black individuals with pigment dispersion and atypical features represents a pigment dispersion syndrome associated with older age, hyperopia, and female sex preponderance, in the black race.
Subject(s)
Black People , Glaucoma, Open-Angle/ethnology , Adult , Age Factors , Aged , Aged, 80 and over , Anterior Eye Segment/pathology , Endothelium, Corneal/pathology , Female , Glaucoma, Open-Angle/pathology , Humans , Hyperopia/etiology , Intraocular Pressure , Louisiana/epidemiology , Male , Middle Aged , Prospective Studies , Sex Factors , Trabecular Meshwork/pathologyABSTRACT
Piperacillin was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. Doses ranged from 50 micrograms to 3,000 micrograms. Toxicity was determined through histology and electroretinograms by comparing the piperacillin-injected eyes with eyes injected with balanced saline solution. Retinal toxicity was noted in the outer layer of the retina when 3,000 micrograms was injected intravitreally. No toxicity was noted by histology with 1,500 micrograms of piperacillin. The minimal inhibitory concentration of piperacillin is 800 micrograms/cc for both gram negative and gram positive organisms. The large dose of intravitreal piperacillin tolerated by rabbit eyes makes piperacillin a potentially safe and effective broad spectrum antibiotic for the treatment of bacterial endophthalmitis in human eyes.
Subject(s)
Eye/drug effects , Piperacillin/administration & dosage , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Electroretinography , Eye/pathology , Injections , Piperacillin/adverse effects , Rabbits , Vitreous BodyABSTRACT
A 21 year old man developed Pseudomonas aeruginosa keratitis 23 months after a reoperation for radial keratotomy. The ulcer developed in one of the inferior incision sites, presumably as a result of poor epithelial wound healing. Prompt medical therapy with fortified antibiotics led to normal visual recovery.
