ABSTRACT
An objective of this paper was to study correlations between cardiac functions and cognitive disorders and to establish a prognostic role of the former in the progression of cerebrovascular pathology. We studied 102 patients, aged from 41-79 years, mean age 60,38±7,89 years. Standard instrumental methods for the study of the cardiovascular system and neuropsychological tests for the assessment of cognitive functions were used along with clinical neurological and somatic examination. It was shown that the age, level of diastolic pressure, atherosclerosis of brain vessels and valvular heart disease predicted cognitive impairment in patients with chronic brain ischemia. Reduced left ventricular ejection fraction was the main cardiac factor determining the severity of cognitive disturbances.
Subject(s)
Brain Ischemia/complications , Cognition Disorders/etiology , Heart Diseases/etiology , Hemodynamics/physiology , Adult , Aged , Chronic Disease , Cognition/physiology , Cognition Disorders/physiopathology , Disease Progression , Female , Heart Diseases/physiopathology , Humans , Male , Middle Aged , Neuropsychological Tests , PrognosisABSTRACT
Forty patients, aged from 55 to 85 years, with post-stroke depression received valdoxan in dosage of 25 mg daily during 3 months. Patient's state was assessed with a battery of scales (The Hamilton depression scale, MMSE, Tinnetti scale etc). The high antidepressive effect and good tolerability of the drug were demonstrated. The improvement of movement and cognitive functions, together with the stabilization of the emotional state, was seen.