[Evolution of the main diagnoses of hospital discharges amongst the prison population in Valencia, 2000-2009]. / Evolución de los principales diagnósticos al alta hospitalaria de la población penitenciaria de la provincia de Valencia, 2000-2009.

The aim of our study was to quantify the hospital demand originating from prisons and describe the main diagnoses as a measure of prevalence, as well as communicable diseases and their evolution during the period 2000-09. Using the discharge records of the University General Hospital under the terms of an agreement that meets the demand for hospitals from prisons in the province of Valencia, we carried out a cross-sectional study of the frequency distribution of diagnoses and their distribution according to personal characteristics. More than 2,415 discharges were recovered, which, after the removal of inconsistencies, provided 2,332 episodes of hospitalization. The average age of the subject ranged from 32.8 to 39.5 years. The most common grouped primary and secondary diagnoses (table 2) were: 1. HIV (34.05%), 2. Hepatitis C (14.67%), 3 º. Drug dependence (10.25%), 4 º. Pneumonia (8.58%), 5. TBC (7.46%). In the last decade there has been a change in the patterns of infection in the prison population. This may be related to: the relative aging of the prison population, the replacement of intravenous use by other non-invasive means, the change of nationality of prisoners and therapeutic advances in the treatment of HIV infection.

Evolución de los principales diagnósticos al alta hospitalaria de la población penitenciariade la provincia de Valencia, 2000-2009 / Evolution of the main diagnoses of hospital discharges amongst the prison population in valencia, 2000-2009

El objetivo de nuestro trabajo ha sido cuantificar la demanda hospitalaria de origen penitenciario y caracterizar los principales diagnósticos como una medida de prevalencia y las patologías transmisibles y su evolución durante el periodo 2000-09. A partir del registro de altas del Consorcio Hospital General Universitario que atiende por convenio la demanda hospitalaria de los centros penitenciarios de Valencia provincia, se realizo un estudio transversal de las frecuencias de los diagnósticos y su distribución de acuerdo a las características personales. Se recuperaron 2.415 altas que tras la eliminación de inconsistencias aportaron 2.332 episodios de hospitalización. La edad media de los sujetos evolucionó desde 32,8 a 39,7 años. Los diagnósticos principales y secundarios agrupados (tabla 2) más frecuentes fueron: 1º. VIH (34,05%), 2º. Hepatitis C (14,67%), 3º. Dependencia Drogas (10,25%), 4º. Neumonías (8,58%), 5º. TBC (7,46%). A lo largo de la década se ha producido un cambio en el patrón infeccioso de la población penitenciaria que podemos considerar relacionado con: el envejecimiento relativo de la población reclusa, la sustitución de la vía intravenosa por otras vías no invasivas, el cambio relativo del origen nacional de los reclusos y los avances terapéuticos en el tratamiento de la infección por VIH(AU)

The aim of our study was to quantify the hospital demand originating from prisons and describe the main diagnoses as a measure of prevalence, as well as communicable diseases and their evolution during the period 2000-09. Using the discharge records of the University General Hospital under the terms of an agreement that meets the demand for hospitals from prisons in the province of Valencia, we carried out a cross-sectional study of the frequency distribution of diagnoses and their distribution according to personal characteristics. More than 2,415 discharges were recovered, which, after the removal of inconsistencies, provided 2,332 episodes of hospitalization. The average age of the subject ranged from 32.8 to 39.5 years. The most common grouped primary and secondary diagnoses (table 2) were: 1. HIV (34.05%), 2. Hepatitis C (14.67%), 3 º. Drug dependence (10.25%), 4 º. Pneumonia (8.58%), 5. TBC (7.46%). In the last decade there has been a change in the patterns of infection in the prison population. This may be related to: the relative aging of the prison population, the replacement of intravenous use by other non-invasive means, the change of nationality of prisoners and therapeutic advances in the treatment of HIV infection(AU)

Dentinal permeability in assessing therapeutic agents.

The measurement of dentinal permeability has been useful in confirming the mechanism of the hydrodynamic hypothesis for pain transmission in hypersensitive patients, has advanced our understanding of how neural agents can reach the pulpal nerves, and has provided useful data to compare and evaluate therapeutic agents. Methods to assess permeability have varied from direct dye penetration techniques to measurement of fluid flow through dentin sections to SEM photography of impression replicas in vivo. A number of clinical therapeutic strategies have emerged from this work as well as ways to mitigate the progressive nature of the condition.

Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.

Considerable evidence has demonstrated the importance of PGE2 synthesis in the pathogenesis of periodontal disease. Although various cyclooxygenase inhibitors have been known to block periodontal PGE2 synthesis and prevent disease progression in animal models, there are few reports comparing relative efficacies of various inhibitors of arachidonic acid (ARA) metabolism. We have developed a sensitive in vitro assay to measure PGE2 synthesis in periodontal tissues. The apparent IC50 values (i.e. the concentration of drug which causes 50% inhibition of maximum PGE2 synthesis) have been determined for a series of arachidonic acid analogues as well as competitive and non-competitive cyclooxygenase inhibitors. Periodontal tissue homogenates were incubated in the presence of 3H-arachidonic acid for 45 min at 37 degrees C. Inhibitors were tested at 10(-10)-10(-4) M and at zero concentration to measure conversion of 3H-arachidonate to 3H-PGE2. Log or half log dilutions of inhibitors were tested in triplicate for each assay. Radiolabeled PGE2 was extracted from homogenates, purified by reverse phase chromatography and quantitated by double antibody capture. RIA was performed on each homogenate to determine the amount of endogenous unlabeled PGE2 present in the sample to correct for antibody capture recovery. The apparent IC50 values were determined for each drug by averaging two or more replicate assays. Specific total enzymatic activity of periodontal tissue homogenates was typically 5-11 pg PGE2/min/mg tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

Simultaneous determination of potassium nitrate and sodium monofluorophosphate in dentifrices by single column ion chromatography.

The simultaneous determination of potassium nitrate and sodium monofluorophosphate in dentifrices by single column ion chromatography is described. Nitrate and monofluorophosphate are extracted from the dentifrice with deionized water and separated by a low capacity anion separator column with 0.2% sodium benzoate (adjusted to pH 5.8 +/- 0.1 with formic acid) as the mobile phase. A conductivity meter is used for concentration measurements. The method has been applied to commercial dentifrices containing both potassium nitrate and sodium monofluorophosphate. The mean recoveries for potassium nitrate and monofluorophosphate from spiked samples were 99.0% and 99.2%, respectively, with corresponding standard deviations of 1.73% and 2.55%. The minimum detectable concentration is 5 micrograms/ml for both nitrate and monofluorophosphate.

Simultaneous determination of nitrate and nitrite in toothpastes by high-performance liquid chromatography.

A stability-indicating analytical method is described for the simultaneous determination of nitrate, and if present, its reductive degradation product, nitrite, in toothpastes. Nitrate and nitrite were extracted from the toothpaste using distilled water and separated from other water-soluble excipients by two RP-8 columns (250 mm X 4 mm i.d.) using a mobile phase containing 0.2% (w/v) sodium acetate and 2.5% (v/v) glacial acetic acid in distilled water. A UV detector set at 313 nm was used for quantitation. The method was applied to commercial toothpastes containing 5% potassium nitrate and yielded an average recovery of 100.1% with a relative standard deviation of 1.43%. Average recovery of nitrate and nitrite from spiked samples were 100.6% and 96.4%, respectively. The minimum detectable concentration for nitrite was 50 micrograms/g of toothpaste.

Stability assay of allantoin in lotions and creams by high-pressure liquid chromatography.

A high-pressure liquid chromatographic method for indicating stability is described for the rapid quantitative analysis of allantoin in lotions and creams. Allantoin was extracted from the preparations using distilled water containing 70% (v/v) methanol and separated from interferences by reversed-phase chromatography. The separation was carried out using an amino column (250 X 4.5-mm i.d.) and a mobile phase of distilled water containing 70% (v/v) acetonitrile. Quantitation was accomplished using a UV detector at 220 nm. The assay has a relative standard deviation of approximately 1.7% (n = 10) and the average recovery from laboratory prepared samples was 100%.

Stability-indicating assay of acetaminophen in an effervescent tablet by ion-pair high-performance liquid chromatography.

A stability-indicating analytical method is described for determining acetaminophen and its degradation product, p-aminophenol, in an affervescent tablet. Tablets assayed by ion-pair high-performance reversed-phase liquid partition chromatography required no sample cleanup. The method applied to tablets containing 325 mg of acetaminophen yielded an average recovery of 99.6% with a relative standard deviation of 0.70% (n = 10). As little as 0.005% p-aminophenol could be detected.