Operative techniques and morbidity with subthalamic nucleus deep brain stimulation in 100 consecutive patients with advanced Parkinson's disease.

OBJECTIVE: Subthalamic nucleus (STN) stimulation for patients with medically refractory Parkinson disease (PD) is expanding. Reported experience has provided some indication of techniques, efficacy, and morbidity, but few centres have reported more than 50 patients. To expand this knowledge, we reviewed our experience with a large series of consecutive patients. METHODS: From March 1999 to September 2003, 191 subthalamic stimulator devices (19 unilateral) were implanted in 100 patients with PD at New York Presbyterian Hospital/Columbia University Medical Center. Sixteen patients had undergone a prior surgery for PD (pallidotomy, thalamotomy, or fetal transplant). Microelectrode guided implantations were performed using techniques similar to those described previously. Electrode implantation occurred 1-2 weeks before outpatient pulse generator implantation. RESULTS: Reductions of dyskinesias and off severity/duration were similar to prior published reports. Morbidity included: 7 device infections (3.7%), 1 cerebral infarct, 1 intracerebral haematoma, 1 subdural haematoma, 1 air embolism, 2 wound haematomas requiring drainage (1.0%), 2 skin erosions over implanted hardware (1.0%), 3 periprocedural seizures (1.6%), 6 brain electrode revisions (3.1%), postoperative confusion in 13 patients (6.8%), and 16 battery failures (8.4%). Of the 100 patients, there were no surgical deaths or permanent new neurological deficits. The average hospital stay for all 100 patients was 3.1 days. CONCLUSION: Subthalamic stimulator implantation in a large consecutive series of patients with PD produced significant clinical improvement without mortality or major neurological morbidity. Morbidity primarily involved device infections and hardware/wound revisions.

The stenosis ratio: a new tool for the diagnosis of degenerative spinal stenosis.

CLINICAL RELEVANCE: Low back pain from lumbar spinal stenosis is a significant source of morbidity, especially among the elderly population. Accurate diagnosis is imperative for effective treatment to be initiated. This paper presents a quantitative method for the evaluation of spinal stenosis that, when used in conjunction with CT and MRI, may greatly aid the clinician in the diagnosis of this debilitating condition. OBJECTIVE: Precise clinical tools for the diagnosis of spinal stenosis are severely lacking. Low back pain and dysfunction derived from lumbar spinal stenosis is a significant source of morbidity, especially among the elderly. Despite its importance, there has been little progress made towards establishing valid, quantitative criteria for the diagnosis of spinal stenosis. We present a new quantitative tool for the diagnosis of lumbar stenosis, the Stenosis Ratio (SR). METHODS: CT scans and MRI scans of 43 patients presenting with clinico-radiographic evidence of lumbar stenosis were used. The patient group consisted of 13 males and 30 females between the ages 49 and 82 with average age of 67. CT and MRI/scans of 43 patients were digitized and computer analyzed. Measurements of SR, defined as the ratio of the cross-sectional dural area of the motion segment to that of the stable segment, were established for L3-L4, L4-L5 and L5-S1 stenotic levels and compared to SR values for a non-stenotic (internal control) level, L2-L3. RESULTS: The L4-L5 level had the lowest SR value of 0.71, followed by 0.74 at L3-L4, and 0.87 at L5-S1. Ninety-five percent confidence intervals of (0.66, 0.81), (0.62, 0.81), and (0.73, 1.00) were found for SR values at levels L3-L4, L4-L5 and L5-S1 respectively. The SR at L2-L3 had a mean value of 1.37 with a 95% confidence interval of (0.970, 1.78). At all levels, SRs were significantly lower for the spinal stenotic L3-S1 levels than for the L2-L3 control as confirmed by a student's t-test (p < 0.05). CONCLUSION: In a select population of patients with spinal stenosis confirmed by neuroradiological assessment, values of SRs were consistently and significantly lower than controls. We believe that measurements of SRs may provide reproducible quantitative measures for the diagnosis of spinal stenosis. SR values below the 95% confidence limit may be indicative of lumbar stenosis. Through the use of ratios, inherent differences in patient size are controlled for, thus allowing comparison of values between patients and treatment groups and effective clinical diagnosis of spinal stenosis.

Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures.

We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induced. Here we use primary striatal cultures to permit a more detailed analysis of CRE-2 function and protein binding in relevant neural cell types. By transfection we find that in primary striatal cultures, as in transformed cell lines, the CRE-1 and CRE-2 elements are required for significant induction by cyclic AMP. We report that cyclic AMP induction of the proenkephalin gene in striatal cultures is protein synthesis independent, excluding a role for newly synthesized proteins like c-Fos. We also show that cyclic AMP induces CREB phosphorylation and that phosphorylated CREB interacts strongly with CRE-2 and weakly with CRE-1. The predominant protein bound to CRE-1 is not CREB, however, and remains to be identified. Despite some prior predictions, we do not find a role for c-Fos in cyclic AMP regulation of proenkephalin gene expression in neurons.

Dislocation of the sternoclavicular joint. Evaluation using paraxial computed tomographic reconstruction.

Sternoclavicular dislocations are relatively infrequent, constituting less than 1% of somatic dislocations. Despite the fact that the sternoclavicular joint is the only articulation between the upper extremity and the axial skeleton, it possesses the least amount of osseous stability of any joint in the body. Sternoclavicular dislocations are generally divided into anterior and posterior disruptions, the former being the most common. An unusual case of an anterior dislocation of the sternoclavicular joint with a large superior component is described. It was found that coronal paraxial computed tomographic reconstruction of the joint was quite useful in evaluating this injury.

Stevens-Johnson-type reaction with vancomycin treatment.

OBJECTIVE: To report a case of Stevens-Johnson syndrome caused by vancomycin. CASE SUMMARY: Stevens-Johnson syndrome is an acute mucocutaneous process characterized by epidermal and mucosal desquamation. Its pathogenesis is poorly understood. Mortality rates have ranged from 30 to 100 percent. We describe a case of Stevens-Johnson syndrome related to the use of vancomycin in a 71-year-old woman with rheumatoid arthritis receiving treatment for an infected cervical fusion site. Classic "target" lesions distributed throughout the trunk and extremities along with erosive lesions involving the oral and vaginal mucosae were observed in this patient. DISCUSSION: A number of agents have been implicated in the etiology of Stevens-Johnson syndrome. Serious cutaneous reactions to vancomycin, however, have been uncommon. Cessation of vancomycin treatment in our patient led to eventual resolution of her symptoms. CONCLUSIONS: Vancomycin is a potential causative agent of Stevens-Johnson syndrome.