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1.
Eur Rev Med Pharmacol Sci ; 27(20): 9815-9821, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37916347

ABSTRACT

OBJECTIVE: The efficacy of epidural steroid injections (ESIs) in the treatment of radicular pain in patients undergoing lumbar spinal surgery is still unclear. The aim of this study was to investigate the factors affecting the success of ESIs in the treatment of ongoing radicular pain in patients undergoing lumbar spinal surgery. PATIENTS AND METHODS: This study was designed as a single-center, retrospective study, and was conducted at a Pain Management Center of a tertiary care center. A total of 260 patients with failed back surgery syndrome who received fluoroscopy-guided lumbar ESI were included. Treatment success was defined as ≥50% reduction in the numeric rating scale score at the one-month follow-up. The patients were divided into the treatment success and the treatment failure groups. RESULTS: The presence of spinal instrumentation was significantly lower in the treatment success group (p=0.045). Symptom duration and the numeric rating scale score at 1 hour were significantly lower in the treatment success group (p<0.05). The use of triamcinolone acetonide in the treatment success group was found to be significantly higher than in the treatment failure group (p=0.027). CONCLUSIONS: The short duration of symptoms and the absence of instrumentation seem to be prognostic factors that positively affect the success of ESI treatment in operated patients. A ≥50% pain reduction in the first hour after the procedure is a valuable indicator that treatment success can be achieved in the short term. Finally, the steroid type can also affect the treatment results.


Subject(s)
Pain , Steroids , Humans , Retrospective Studies , Injections, Epidural/methods , Treatment Outcome , Steroids/therapeutic use , Lumbar Vertebrae/surgery
2.
Tumour Biol ; 36(12): 9209-13, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26088448

ABSTRACT

Glioblastoma multiforme (GBM) is one of the most lethal forms of cancer in humans, with a median survival of 10 to 12 months. Glioblastoma is highly malignant since the cells are supported by a great number of blood vessels. Although new treatments have been developed by increasing knowledge of molecular nature of the disease, surgical operation remains the standard of care. The TRP (transient receptor potential) superfamily consists of cation-selective channels that have roles in sensory physiology such as thermo- and osmosensation and in several complex diseases such as cancer, cardiovascular, and neuronal diseases. The aim of this study was to investigate the expression levels of TRP channel genes in patients with glioblastoma multiforme and to evaluate the relationship between TRP gene expressions and survival of the patients. Thirty-three patients diagnosed with glioblastoma were enrolled to the study. The expression levels of 21 TRP genes were quantified by using qRT-PCR with dynamic array 48 × 48 chip (BioMark HD System, Fluidigm, South San Francisco, CA, USA). TRPC1, TRPC6, TRPM2, TRPM3, TRPM7, TRPM8, TRPV1, and TRPV2 were found significantly higher in glioblastoma patients. Moreover, there was a significant relationship between the overexpression of TRP genes and the survival of the patients. These results demonstrate for the first time that TRP channels contribute to the progression and survival of the glioblastoma patients.


Subject(s)
Glioblastoma/genetics , RNA, Messenger/biosynthesis , Transient Receptor Potential Channels/biosynthesis , Aged , Female , Gene Expression Regulation, Neoplastic , Glioblastoma/pathology , Humans , Male , Middle Aged , Multigene Family/genetics , RNA, Messenger/genetics , Survival Analysis , Transient Receptor Potential Channels/genetics
3.
Int J Oral Maxillofac Surg ; 41(10): 1284-90, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22832662

ABSTRACT

The aim of this study was to evaluate the levels of fear and anxiety in patients undergoing different types of minor oral surgery procedures by using conventional rating scales adjusted to the population characteristics. A demographic form and translated versions of the Modified Dental Anxiety Scale (MDAS) and Dental Fear Survey (DFS) were completed by 500 patients having hard or soft tissue pathologies, third molar removal, implant placement, tooth extraction procedures and 200 non-clinical participants. MDAS and DFS were highly correlated (r = 0.79; P < 0.05). The structural properties of the MDAS were similar to the original, but the DFS required substantive changes to achieve comparable measurement properties. Anxiety levels decreased with age and were greater in females, those with higher education and following a previous unpleasant experience (P < 0.05 for all). The third molar group scored higher than most of the surgical categories in both questionnaires (P < 0.05 for each). DFS showed they tended to avoid surgical procedures and were more susceptible to environmental and chair-side effects (P<0.05 for all). Regarding oral surgery, third molar patients should be targeted to increase overall comfort of the treatment. Assessments should be adjusted to cultural differences.


Subject(s)
Ambulatory Surgical Procedures/psychology , Dental Anxiety/etiology , Molar, Third/surgery , Oral Surgical Procedures/psychology , Tooth Extraction/psychology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Ambulatory Surgical Procedures/adverse effects , Chi-Square Distribution , Female , Humans , Male , Manifest Anxiety Scale , Middle Aged , Oral Surgical Procedures/adverse effects , Reproducibility of Results , Sex Factors , Socioeconomic Factors , Surveys and Questionnaires , Tooth Extraction/adverse effects , Turkey , Young Adult
4.
Alcohol Clin Exp Res ; 35(1): 99-107, 2011 Jan.
Article in English | MEDLINE | ID: mdl-21039631

ABSTRACT

BACKGROUND: Neurotensin receptors (NTS) regulate a variety of the biological functions of neurotensin (NT) in the central nervous system. Although NT and neurotensin receptors type 1 (NTS1) are implicated in some of the behavioral effects of ethanol, the functional roles of neurotensin receptors type 2 (NTS2) in ethanol intoxication and consumption remain unknown. Here, we investigated behavioral effects mediated by NTS2 in response to ethanol, which are implicated in ethanol consumption and preference, using NTS2 null mice. METHOD: First, we examined ethanol-induced locomotion, ataxia, hypnosis, and hypothermia in NTS2 null mice. Next, we measured ethanol consumption and preference in NTS2 null mice by giving them free choice between ethanol- and tap water-containing bottles. Then using a brain-permeable NT analog, NT69L, we examined the role of NTS2 in locomotor activity and ataxia. Finally, we examined the effect of NT69L on ethanol consumption and preference in NTS2 null mice. RESULTS: We found that NTS2 null mice appear less sensitive to the acute hypnotic effects of ethanol and consumed more ethanol compared to wild-type littermates in a 2-bottle choice experiment, even though ethanol-induced locomotion, ataxia, and hypothermia were similar between genotypes. Interestingly, the administration of NT69L for 4 consecutive days significantly reduced alcohol consumption and preference in wild-type littermates as well as in NTS2 null mice. CONCLUSIONS: Our findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption.


Subject(s)
Alcohol Drinking/metabolism , Ethanol/administration & dosage , Receptors, Neurotensin/metabolism , Alcohol Drinking/genetics , Animals , Body Temperature , Male , Mice , Mice, Inbred C57BL , Mice, Knockout , Motor Activity , Neurotensin/administration & dosage , Neurotensin/analogs & derivatives , Neurotensin/pharmacology , Peptide Fragments/administration & dosage , Peptide Fragments/pharmacology , Receptors, Neurotensin/genetics , Taste Perception
5.
Dentomaxillofac Radiol ; 39(6): 336-42, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20729182

ABSTRACT

OBJECTIVES: the aim of this study was to compare diagnostic accuracy of cone beam CT (CBCT) and multislice CT in artificially created fractures of the sheep mandibular condyle. METHODS: 63 full-thickness sheep heads were used in this study. Two surgeons created the fractures, which were either displaced or non-displaced. CBCT images were acquired by the NewTom 3G CBCT scanner (NIM, Verona, Italy) and CT imaging was performed using the Toshiba Aquillon multislice CT scanner (Toshiba Medical Systems, Otawara, Japan). Two-dimensional (2D) cross-sectional images and three-dimensional (3D) reconstructions were evaluated by two observers who were asked to determine the presence or absence of fracture and displacement, the type of fracture, anatomical localization and type of displacement. The naked-eye inspection during surgery served as the gold standard. Inter- and intra-observer agreements were calculated with weighted kappa statistics. The receiver operating characteristics (ROC) curve analyses were used to compare statistically the area under the curve (AUC) of both imaging modalities. RESULTS: kappa coefficients of intra- and interobserver agreement scores varied between 0.56 - 0.98, which were classified as moderate and excellent, respectively. There was no statistically significant difference between the imaging modalities, which were both sensitive and specific for the diagnosis of sheep condylar fractures. CONCLUSIONS: this study confirms that CBCT is similar to CT in the diagnosis of different types of experimentally created sheep condylar fractures and can provide a cost- and dose-effective diagnostic option.


Subject(s)
Cone-Beam Computed Tomography , Imaging, Three-Dimensional/methods , Mandibular Condyle/injuries , Mandibular Fractures/diagnostic imaging , Tomography, Spiral Computed , Animals , Area Under Curve , Cone-Beam Computed Tomography/instrumentation , Cost-Benefit Analysis , Fractures, Comminuted/diagnostic imaging , Mandibular Condyle/diagnostic imaging , Observer Variation , ROC Curve , Radiography, Dental, Digital/methods , Reproducibility of Results , Sheep, Domestic , Tomography, Spiral Computed/instrumentation
6.
Pharmacol Biochem Behav ; 95(2): 235-41, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20122953

ABSTRACT

Neurotensin receptor type 1 (NTS1) is known to mediate a variety of biological functions of neurotensin (NT) in the central nervous system. In this study, we found that NTS1 null mice displayed decreased sensitivity to the ataxic effect of ethanol on the rotarod and increased ethanol consumption when given a free choice between ethanol and tap water containing bottles. Interestingly, the administration of NT69L, a brain-permeable NT analog, increased ethanol sensitivity in wild-type littermates but had no such effect in NTS1 null mice, suggesting that NTS1 contributes to NT-mediated ethanol intoxication. Furthermore, the daily treatment of NT69L, for 4 consecutive days, significantly reduced alcohol preference and consumption in wild-type littermates but had no such effects in NTS1 null mice in a two-bottle drinking experiment. Our study provides evidence for possible pharmacological roles of NT69L in which it increases sensitivity to the ataxic effect, and decreases voluntary consumption, of ethanol. Our study also demonstrates NTS1-mediated behavioral effects of NT69L. Therefore, our findings will be useful for understanding some aspects of alcoholism as well as to develop novel pharmacological therapeutic options for humans.


Subject(s)
Ethanol/toxicity , Receptors, Neurotensin/physiology , Animals , Base Sequence , DNA Primers , Ethanol/administration & dosage , Male , Mice , Mice, Inbred C57BL , Mice, Knockout , Receptors, Neurotensin/genetics
7.
Psychopharmacol Bull ; 42(3): 39-54, 2009.
Article in English | MEDLINE | ID: mdl-19752840

ABSTRACT

OBJECTIVES: Existing efficacy trials of Omega-3 (omega-3) fatty acids in mood disorders have yielded inconsistent results. The current paper is an effort to provide a systematic review and meta-analysis to evaluate efficacy of omega-3 fatty acids in treatment of mood disorders. DESIGN: We searched Medline, Embase, PsychInfo, and the Cochrane Controlled Trials registry up to June 2008 for randomized trials investigating efficacy of omega-3 fatty acids in mood disorders.We conducted random effects meta-analyses.We used the I2 statistic to quantify between-study inconsistency, and conducted pre-specified subgroup analyses to explore potential explanations for inconsistency. OBSERVATIONS: We included 21 trials in our systematic review and found 13 trials to be eligible for meta-analysis. The pooled standardized mean difference in depressed mood states (n = 554 in 12 trials) was -0.47 (95% CI:-0.92,-0.02; I2 = 82.7; p = 0.07) and in manic mood states (n = 126 in 4 trials) was 0.22 (95% CI: -0.21, 0.65; I2 = 40.5; p = 0.31).We did not identify any treatment- subgroup interaction across forms of omega-3 fatty acids preparations (P = 0.99) or patient diagnosis (bipolar vs. unipolar depressive disorder; P = 0.96); there was a significant correlation between omega-3 fatty acids dose and treatment effect on depressive symptoms (r = 0.5, p = 0.04), but not on manic symptoms (P = 0.3). CONCLUSIONS: The available evidence suggests that omega-3 fatty acids are a potential treatment of depressive disorders, but not mania. The unexplained between-study inconsistency and imprecision of the pooled estimates mitigate this suggestion. Large randomized placebo-controlled trials are needed to better estimate the value of this intervention for patients with depression.


Subject(s)
Bipolar Disorder/drug therapy , Depressive Disorder/drug therapy , Fatty Acids, Omega-3/therapeutic use , Dose-Response Relationship, Drug , Fatty Acids, Omega-3/administration & dosage , Humans , Randomized Controlled Trials as Topic , Treatment Outcome
8.
Psychiatry Res ; 162(2): 113-21, 2008 Feb 28.
Article in English | MEDLINE | ID: mdl-18164911

ABSTRACT

The objective of this study was to determine whether cerebrospinal fluid(CSF)-corrected concentrations of N-acetylaspartate are lower in several brain regions of drug- and medication-free subjects with bipolar disorder as compared with matched healthy controls. Bipolar subjects (n=21) and age- and sex-matched healthy control (n=21) were studied using proton magnetic resonance spectroscopic imaging on a 3T magnetic resonance (MR) scanner. Spectra were quantified using the LCModel, and metabolite values were CSF-corrected to yield metabolite concentrations. Fourteen regions of interest and five metabolite concentrations in each subject were selected for statistical analysis. We found that bipolar subjects had significantly decreased N-acetylaspartate concentrations in both caudate heads and the left lentiform nucleus. Choline and creatine in the head of the right caudate were also significantly decreased in bipolar subjects. Significantly increased myo-inositol was found in the left caudate head in bipolar subjects. Bipolar subjects showed significantly decreased glutamate/glutamine concentrations in the frontal white matter bilaterally and in the right lentiform nucleus. No differences were found for other metabolites examined. These preliminary findings suggest decreased neuronal density or viability in the basal ganglia and neurometabolic abnormalities in the frontal lobes of subjects with bipolar disorder.


Subject(s)
Bipolar Disorder/cerebrospinal fluid , Brain/physiopathology , Energy Metabolism/physiology , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Adolescent , Adult , Aspartic Acid/analogs & derivatives , Aspartic Acid/cerebrospinal fluid , Basal Ganglia/physiopathology , Bipolar Disorder/diagnosis , Case-Control Studies , Caudate Nucleus/physiopathology , Corpus Striatum/physiopathology , Creatine/cerebrospinal fluid , Cross-Sectional Studies , Dominance, Cerebral/physiology , Female , Frontal Lobe/physiopathology , Glutamic Acid/cerebrospinal fluid , Glutamine/cerebrospinal fluid , Humans , Inositol/cerebrospinal fluid , Male , Middle Aged , Reference Values
9.
Bioresour Technol ; 84(3): 291-3, 2002 Sep.
Article in English | MEDLINE | ID: mdl-12118709

ABSTRACT

Activated carbon prepared from hazelnut shell was used as an adsorbent for the removal of Ni(II) from aqueous solution. Batch mode adsorption studies were carried out by varying initial metal ion concentration, agitation speed, temperature and particle size. A contact time of 180 min was required to reach equilibrium. The equilibrium data were analysed using the Langmuir, Freundlich and Temkin isotherms. The characteristic parameters for each isotherm were determined. The Langmuir isotherm provided the best correlation for Ni(II) onto the activated carbon. Thermodynamical parameters revealed that the adsorption of Ni(II) is exothermic in nature.


Subject(s)
Carbon/chemistry , Nickel/chemistry , Water/chemistry , Adsorption , Biotechnology , Corylus , Hydrogen-Ion Concentration , Nickel/analysis , Temperature , Thermodynamics , Time Factors
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