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Appl Immunohistochem Mol Morphol ; 19(1): 76-81, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20823767

ABSTRACT

The clinicopathologic features of the first case of a thymoma with a strong nuclear expression of thyroid transcription factor-1 are reported. The thymoma was classified as type AB according to the WHO-system. No definitive correlation between the different histologic patterns or neoplastic cell types and thyroid transcription factor-1 expression was discerned. No immunohistochemical evidence of neuroendocrine differentiation was identified with synaptophysin, chromogranin A, and CD56.


Subject(s)
Cell Nucleus , Gene Expression Regulation, Neoplastic , Neoplasm Proteins/biosynthesis , Nuclear Proteins/biosynthesis , Transcription Factors/biosynthesis , Antigens, Differentiation/metabolism , Cell Differentiation , Cell Nucleus/metabolism , Cell Nucleus/pathology , Humans , Male , Middle Aged , Neoplasms, Glandular and Epithelial/metabolism , Neoplasms, Glandular and Epithelial/pathology , Thymus Neoplasms/metabolism , Thymus Neoplasms/pathology , Thyroid Nuclear Factor 1
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