ABSTRACT
BACKGROUND: The link between preoperative fasting and hypovolaemia remains unclear. We tested the hypothesis that preoperative fasting does not significantly increase the proportion of patients with hypovolaemia according to transthoracic echocardiography (TTE) criteria. METHODS: Patients of ASA status I-III and without bowel preparation were included in a non-inferiority, prospective, single-centre trial. Patients underwent passive leg raising (PLR) test and TTE at admission (Day 0) and after 8 h fasting (Day 1). The primary hypothesis was that an 8 h preoperative fasting does not increase the proportion (margin=5%) of patients with a positive PLR test ('functional approach'). The secondary hypothesis was that echocardiographic filling pressures or stroke volume (margin 10%) are not affected by preoperative fasting ('static approach'). RESULTS: One hundred patients were included and 98 analysed. After an 8 h fasting, the change in the proportion of responders to PLR was -6.1% [95% confidence interval (CI)=-16.0 to 3.8] of responders to PLR test on Day 0 when compared with Day 1. Because 95% CI was strictly inferior to 5%, there was no significant increase in the proportion of PLR responders on Day 1 when compared with Day 0. The 95% CI changes of static variables were always fewer than 10%, meaning that preoperative fasting induced significantly no relevant changes in static variables. CONCLUSION: Preoperative fasting did not alter TTE dynamic and static preload indices in ASA I-III adult patients. These results suggest that preoperative fasting does not induce significant hypovolaemia. Clinical trial registration NCT 01258361.
Subject(s)
Echocardiography/methods , Fasting/physiology , Hemodynamics/physiology , Hypovolemia/diagnosis , Preoperative Care/methods , Female , Humans , Male , Middle Aged , Prospective Studies , Stroke Volume/physiologyABSTRACT
AIM: The aim of our study was to assess the link between pelvic organ prolapse (POP) characteristics and sexual well-being using validated tools. MATERIAL: A prospective analysis was carried out in 148 women with a POP. The degree of prolapse was measured by using the Pelvic Organ Prolapse Quantification (POPQ). Pelvic Floor Distress Inventory (PFDI-20) questionnaire score was used to estimate the severity of symptoms. Pelvic Organ Prolapse Urinary Incontinence Sexual Questionnaire short form (PISQ-12) scores determined sexual function level. RESULTS: No correlation was found concerning the global sexual function score and the POP stage (P=0.24). Pelvic and urinary symptoms were associated with a decrease in sexual function score (P=0.04 and P=0.002). Defecation symptoms were correlated with decreased sexual satisfaction (P ≤ 0.05) and were associated with premature ejaculation (P ≤ 0.05). Urinary symptoms were associated with dyspareunia (P ≤ 0.01), avoidance of sexual activities (P ≤ 0.05), negative emotions during intercourse (P ≤ 0.01) and decreased sexual excitement (P ≤ 0.05). Pelvic symptoms were significantly tied to avoidance of sexual activities (P ≤ 0.01), dyspareunia (P ≤ 0.05) and a poorer orgasm quality (P ≤ 0.05). CONCLUSION: The degree of pelvic organ prolapse was not statistically associated with sexual function. However, urinary, pelvic and defecatory (ano-rectal) symptoms were associated with a decrease in the couple's sexual well-being.
