1.
Int Arch Allergy Immunol
; 116(1): 81-2, 1998 May.
Article
in English
| MEDLINE
| ID: mdl-9623514
ABSTRACT
A 2-week program of feeding protein antigens as an oil-in-water emulsion to naive mice elicited a significant serum IgG antibody response, whereas their aqueous preparations did not at all. The unresponsive immune state that had been developed after feeding aqueous antigen was not disturbed by subsequent oral challenge with the same antigen in the presence of oil. These results suggest that the principle of oral tolerance is a feasible strategy for prophylaxis of hypersensitization to protein antigens, where protein tolerogens, in this case, are to be given without any additives at their first introduction.
Subject(s)
Antigens/administration & dosage , Dietary Proteins/administration & dosage , Dietary Proteins/immunology , Emulsions/administration & dosage , Administration, Oral , Animals , Antibody Formation , Antigens/immunology , Food Hypersensitivity/prevention & control , Immune Tolerance/drug effects , Immune Tolerance/immunology , Immunoglobulin G/blood , Immunoglobulin G/drug effects , Immunoglobulin G/immunology , Lactoglobulins/administration & dosage , Lactoglobulins/immunology , Mice , Mice, Inbred BALB C , Oils , Solutions/administration & dosage , Water
2.
Kyobu Geka
; 41(13): 1073-6, 1988 Dec.
Article
in Japanese
| MEDLINE
| ID: mdl-3221587
3.
Nihon Kyobu Geka Gakkai Zasshi
; 31(4): 527-32, 1983 Apr.
Article
in Japanese
| MEDLINE
| ID: mdl-6875327