Subject(s)
Carcinoma, Squamous Cell , Tongue Neoplasms , Child , Deafness , Humans , Ichthyosis , SyndromeABSTRACT
In a masked, randomized, concurrently controlled clinical trial we compared the therapeutic response of two regimens in which the same topical corticoid was used to treat 52 men who had stable psoriasis. One regimen, called reduced dose, consisted of once-a-day application of a representative potent fluorinated topical steroid ointment, fluocinonide (Lidex), combined with three-times-a-day application of its vehicle. The other regimen, called traditional dose, consisted of four-times-a-day topical application of the same steroid. Patients were assigned to one of the two regimens and observed for six weeks. Confidence intervals for the difference in true mean response under these two regimens provide good evidence that for these patients the traditional dose was not clinically superior to the reduced dose.
Subject(s)
Fluocinolone Acetonide/analogs & derivatives , Fluocinonide/administration & dosage , Psoriasis/drug therapy , Administration, Topical , Aged , Chronic Disease , Clinical Trials as Topic , Drug Administration Schedule , Humans , Male , Middle Aged , Random AllocationSubject(s)
Carcinoma, Squamous Cell/complications , Ichthyosis/complications , Skin Neoplasms/complications , Adolescent , Child , Humans , MaleABSTRACT
A patient has been studied in whom an atypical ichthyosiform erythroderma was associated with congenital neurosensory deafness, vascularization of the corneas progressing to blindness, alopecia totalis, abnormalities of the teeth and nails, and postnatal growth deficiency. Twelve other patients with a similar pattern of malformation have been reported previously. This syndrome appears to represent a distinct disorder with a pattern of inheritance which is most likely autosomal recessive.
