ABSTRACT
Background: Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear. Aim: The current study has been aimed at analysing the genetic interrelationship between anemia and COPD in accordance with different altitudes. Methodology. The genetic analysis was performed in the SERPINA1 gene of anemia, COPD, and healthy individuals for the analysis of single nucleotide polymorphism at rs28949274 and rs17580 locations. Result and Discussion. The single nucleotide polymorphism at the locations rs28949274 and rs17580 was present in both anemic and COPD patients. The COPD patients were more prone to mutations (63% had rs28949274, and 11% had rs17580 polymorphisms) than the anemic patients (40% had rs28949274, and 1% had rs17580 polymorphisms). On the basis of altitude, high-altitude individuals were found to be more susceptible to both the polymorphisms. Conclusion: Based on the current findings, we suggest that the SERPINA1 gene has a positive correlation with anemia as well as COPD, and the increase in altitude also influences the diseased conditions in a positive manner.
Subject(s)
Anemia , Pulmonary Disease, Chronic Obstructive , Humans , Pulmonary Disease, Chronic Obstructive/genetics , Polymorphism, Single Nucleotide , Risk Factors , Genetic Predisposition to Disease , Case-Control Studies , alpha 1-Antitrypsin/geneticsABSTRACT
The genus Phaneroptera (Tettigoniidae: Orthoptera) has been represented in India by four species. One additional species of Phaneroptera is described based on the variation in lateral lobe of pronotum, cerci of male and modifications of the subgenital plate. The morphometrics of the species are presented, which include P. spinosa, P. gracilis, P. falcata, P. myllocerca and Phaneroptera rentzi sp. nov. Key to the species of the genus Phaneroptera in India is provided.
Subject(s)
Orthoptera , Animal Structures , Animals , Body Size , India , Male , Organ SizeABSTRACT
The present study deals with description of a new species (â) Trigonocorypha thenensis sp. nov. in the genus Trigonocorypha from Tamilnadu, India.
