ABSTRACT
Introducción Es frecuente que la suspensión de aporte de tiroxina como preparación para un rastreo-ablación se prolongue durante 4 semanas, en las que es habitual la aparición de clínica de hipotiroidismo. Una alternativa útil en algunos casos es utilizar TSHhr, pero sus problemas de disponibilidad durante el año 2012 limitarán su uso. Pacientes y métodos Se realizó un análisis de la concentración de TSH y T4 libre en los días 7, 14, 21 y 28 desde el momento de la realización de una tiroidectomía total (12 pacientes) o desde la suspensión del tratamiento con tiroxina (20 pacientes). Se usó el test de Mann Wittney para analizar las comparaciones de variables cuantitativas y el Chi-cuadrado para las nominales. Resultados En el día 14, la concentración plasmática de TSH fue igual o superior a (..) (AU)
Background It is a usual practice to discontinue thyroxine treatment for four weeks before 131I ablation. Symptoms of hypothyroidism usually occur during this time. Use of rhTSH is a helpful alternative in some cases, but problems of availability of this agent during 2012 will limit its use. Patients and methods Plasma TSH and FT4 levels were measured on days 7, 14, 21, and 28 after total thyroidectomy (12 patients) or discontinuation of thyroxine treatment (20 patients). A Mann-Whitney U test was used to compare quantitative variables, and a Chi-square test was used for nominal variables. Results On day 14, TSH levels were (..) (AU)
Subject(s)
Humans , Thyroxine , Thyroidectomy , Hypothyroidism/chemically induced , Thyroid Neoplasms/surgery , Thyroid Function Tests , Postoperative Complications/drug therapyABSTRACT
BACKGROUND: It is a usual practice to discontinue thyroxine treatment for four weeks before (131)I ablation. Symptoms of hypothyroidism usually occur during this time. Use of rhTSH is a helpful alternative in some cases, but problems of availability of this agent during 2012 will limit its use. PATIENTS AND METHODS: Plasma TSH and FT4 levels were measured on days 7, 14, 21, and 28 after total thyroidectomy (12 patients) or discontinuation of thyroxine treatment (20 patients). A Mann-Whitney U test was used to compare quantitative variables, and a Chi-square test was used for nominal variables. RESULTS: On day 14, TSH levels were 30µIU/mL of higher in 71% of patients (66% in the thyroidectomy group and 75% in the group discontinued thyroxine treatment). On day 21, almost all patients from both groups (91% in the thyroidectomy group and 100% in the group discontinued thyroxine treatment) had TSH levels of 30µIU/mL or higher. On day 14, most patients in both groups had FT4 levels below the normal range. CONCLUSIONS: Discontinuation of thyroxine treatment for four weeks is not required. Fourteen days is an adequate time in most patients, and 21 days are sufficient in virtually all patients.
