ABSTRACT
Parachordoma is a very rare soft tissue tumor with histological features similar to chordoma and chondrosarcoma. It should be distinguished from metastatic chordoma and extraskeletal myxoid chondrosarcoma because of its different treatment and prognosis. In this paper we report one case of parachordoma in a 20-year-old female patient. The tumor occurred in the subcutaneous tissue of the left hand as a painless, fixed, slow-growing mass. Pathologic analysis revealed a tumor composed of lobules of cells with variably vacuolated cytoplasm (physaliphorous cells) separated by fibrous septa, predominantly arranged in peculiar small or large alveolar structures. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin 8/18, S-100 protein and vimentin. The patient is well and without recurrence 20 months after surgery.
Subject(s)
Chordoma/diagnosis , Hand , Adult , Chordoma/pathology , Chordoma/surgery , Diagnosis, Differential , Epithelioid Cells , Female , Humans , ImmunohistochemistryABSTRACT
This report describes a case of atypical carcinoid of the larynx with metastatic tumor to cervical lymph nodes showing features similar to paraganglioma. Immunohistochemically, both the primary and metastatic tumor were positive for epithelial membrane antigen, cytokeratin, neuron-specific enolase, chromogranin, synaptophysin, calcitonin and carcinoembryonic antigen. The sustentacular cells in pseudo-cell ball ("Zellballen") formations were shown by a positive S-100 marker. Electron microscopic analysis revealed numerous neuroendocrine granules measuring 150-250 nm in diameter. Clinical features, histological appearance, histochemical, immunohistochemical and ultrastructural findings, as well as differential diagnosis are discussed.
Subject(s)
Carcinoid Tumor/pathology , Laryngeal Neoplasms/pathology , Lymphatic Metastasis/pathology , Aged , Calcitonin/analysis , Carcinoembryonic Antigen/analysis , Carcinoid Tumor/secondary , Chromogranins/analysis , Cytoplasmic Granules/ultrastructure , Diagnosis, Differential , Humans , Immunohistochemistry , Keratins/analysis , Male , Microscopy, Electron , Mucin-1/analysis , Neck , Paraganglioma/diagnosis , Phosphopyruvate Hydratase/analysis , S100 Proteins/analysis , Synaptophysin/analysisABSTRACT
In recent years, breast-conserving therapy and radiation therapy have become an important treatment option for patients with stage I and II invasive breast cancer. The results of long-term retrospective studies have demonstrated that this treatment can provide a high level of local tumor control with satisfactory cosmetic results. Numerous studies have shown that the presence of extensive intraductal component (prominent intraductal carcinoma) is highly associated with subsequent local recurrence. In this article we have stressed the value of the determination of the presence and the histologic grade of prominent intraductal component of invasive ductal breast carcinoma in the determination of the extent of surgery. We also point out the possibility of determination of prominent DCIS on frozen sections.
