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Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam.

Moosavi-Movahedi, A A; Sepassi Tehrani, H; Amanlou, M; Soltani Rad, M N; Hakimelahi, G H; Tsai, F-Y; Ataie, G; Saboury, A A; Ahmad, F; Khalafi-Nezhad, A; Poursasan, N; Sharifizadeh, A.

Protein Pept Lett ; 17(2): 197-205, 2010 Feb.

Article in English | MEDLINE | ID: mdl-20214645

ABSTRACT

Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

Subject(s)

Adenosine Deaminase/chemistry , Adenosine Deaminase/metabolism , Enzyme Inhibitors/metabolism , Lorazepam/metabolism , Oxazepam/metabolism , Adenosine/metabolism , Adenosine Deaminase Inhibitors , Animals , Anti-Anxiety Agents/metabolism , Anticonvulsants/metabolism , Cattle , Circular Dichroism , Computer Simulation , Hypnotics and Sedatives/metabolism , Intestinal Mucosa/enzymology , Kinetics , Ligands , Models, Molecular , Protein Conformation , Spectrometry, Fluorescence , Structure-Activity Relationship , Temperature

ABSTRACT

Subject(s)

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