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1.
J Vasc Access ; 24(2): 213-221, 2023 Mar.
Article in English | MEDLINE | ID: mdl-34162276

ABSTRACT

BACKGROUND: The COVID 19 pandemic adversely impacted delivery of preventive, routine, urgent, and essential care worldwide. Dialysis access care was particularly affected due to the lack of specific guidelines regarding procedures for its creation and maintenance. Early guidance by Centers for Medicare and Medicaid was inadvertently interpreted as guidance to stop dialysis access procedures. Prompt action by professional societies was needed to furnish detailed guidance to establish essential nature of these procedures. METHODS: The American Society of Diagnostic and Interventional Nephrology (ASDIN) issued a joint statement with Vascular Access Society of the Americas (VASA) - "Maintaining Lifelines for ESKD Patients" to clearly establish the role of vascular access as a lifeline for ESKD (End Stage Kidney Disease) patients and the importance and urgency of its timely management. ASDIN also conducted a survey in mid-2020, that was administered to the ASDIN database as well as shared with the general public via the organization's social media platforms. The respondents reported their experiences in the care of dialysis access, practice patterns and the utility of the ASDIN-VASA statement during the COVID 19 pandemic. RESULTS: Of the 2030 individual surveys sent, 581 were opened and 53 (9.1%) responses were received from different parts of the country and from different practice settings. ASDIN COVID 19 triage document was frequently utilized and 83% of respondents found the document valuable. The survey also revealed multiple obstacles, including logistical and financial issues that led to significant disruption of services. CONCLUSIONS: The care of dialysis access was significantly affected in the United States during the COVID 19 pandemic due to multiple reasons. ASDIN actions provided valuable specific guidance regarding and explored barriers to dialysis access care. We describe those results and discuss strategies to prevent COVID 19 transmission with innovative strategies of providing access care. Individualized decision making is of essence when considering dialysis access procedures.


Subject(s)
COVID-19 , Kidney Failure, Chronic , Nephrology , Humans , Aged , United States , Renal Dialysis , Medicare , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/therapy
2.
J Vasc Access ; 23(6): 950-955, 2022 Nov.
Article in English | MEDLINE | ID: mdl-33947278

ABSTRACT

Arteriovenous fistula (AVF) thrombosis occurs less often when compared to arteriovenous grafts. Since the number of AVFs has increased in the United States, AVF thrombosis is seen more frequently today. AVF thrombectomy can be tedious, requires physician ingenuity, and many times results in failure. Substantial clot burden in megafistulas and aneurysms is considered a relative contraindication to endovascular thrombectomy. Usually, it results in surgical referral for open thrombectomy or, at times, abandonment of the fistula altogether. Herein, we describe the technique, results, and cautions of combining a continuous infusion of recombinant tissue plasminogen (rTPA) followed by angioplasty of the culprit stenotic lesion that was successful in opening five of six AVFs with a substantial clot burden.


Subject(s)
Arteriovenous Fistula , Arteriovenous Shunt, Surgical , Thrombosis , Humans , Arteriovenous Shunt, Surgical/adverse effects , Vascular Patency , Renal Dialysis , Treatment Outcome , Thrombosis/diagnostic imaging , Thrombosis/drug therapy , Thrombosis/etiology , Fibrinolytic Agents/pharmacology , Thrombectomy/methods , Catheters , Plasminogen/pharmacology , Retrospective Studies
3.
Adv Chronic Kidney Dis ; 27(3): 253-262, 2020 05.
Article in English | MEDLINE | ID: mdl-32891310

ABSTRACT

The cost and health burden of ESRD continues to increase globally. Total Medicare expenditure on dialysis has increased from 229 million USD in 1973 to 35.4 billion USD in 2016. Dialysis access can represent almost a tenth of these costs. Central venous catheters have been recognized as a significant factor driving costs and mortality in this population. Home dialysis, which includes peritoneal dialysis and home hemodialysis, is an effective way of reducing costs related to renal replacement therapy, reducing central venous catheter usage and in many cases improving the clinical and psychosocial aspects of patients' health. Addressing access-related issues for peritoneal dialysis, urgent-start peritoneal dialysis and home hemodialysis can have impact on the success of home dialysis. This article reviews issues related to dialysis access for home therapies.


Subject(s)
Hemodialysis, Home , Kidney Failure, Chronic/therapy , Arteriovenous Shunt, Surgical , Health Services Accessibility , Hemodialysis, Home/economics , Hemodialysis, Home/methods , Humans , Kidney Failure, Chronic/epidemiology , Medicare/economics , United States/epidemiology
4.
Biomed Instrum Technol ; 54(1): 37-43, 2020.
Article in English | MEDLINE | ID: mdl-31961742

ABSTRACT

Hydrophilic polymer coatings on intravascular devices lower friction between the device and vasculature, thereby reducing trauma during interventional procedures. Polymer coating embolism-the detachment and downstream embolism of polymer particles-has been reported as an iatrogenic complication of coated interventional devices affecting the vasculature and various organs. The Food and Drug Administration (FDA) acknowledges this complication and continues to work with stakeholders to close gaps in performance testing and standards related to polymer coating integrity. Recent innovations within interventional technologies have led to development of new hydrophilic-coated devices with expanded indications for use. The 2018 FDA draft guidance for intravascular guidewires expands the application of particulate generation testing to most devices and recommends labeling changes to increase industry awareness. This article highlights current procedural trends where the phenomenon of polymer coating embolism may be more prevalent. It describes the mechanisms of polymer separation, reported clinical sequelae, and risk factors for relevant indications. These procedural trends and associated risk factors articulate the need for particulate testing and support the FDA's draft guidance recommendations for performance testing of applied coatings. If standardized, particulate assessments may allow characterization and comparisons of coating integrity among devices from various manufacturers, and are an important foundation for setting particulate limits. As hydrophilic coatings enable endovascular treatment for a range of patient populations, setting particulate limits or finding alternative solutions without compromise to device function may be essential. Particulate testing is relevant to physicians, regulators, and manufacturers for the purposes of product development and quality improvement of interventional devices.


Subject(s)
Embolism , Coated Materials, Biocompatible , Humans , Hydrophobic and Hydrophilic Interactions , Polymers , United States , United States Food and Drug Administration
5.
J Vasc Access ; 19(4): 341-345, 2018 Jul.
Article in English | MEDLINE | ID: mdl-29529961

ABSTRACT

Stents are ubiquitously utilized in coronary and peripheral arterial disease. Interventional nephrologists, however, place stents in the venous outflow of the arteriovenous access. Stenosis is the predominant pathology that causes access dysfunction and will ultimately lead to thrombosis if uncorrected. Angioplasty and stent deployment are the current techniques available to combat stenosis. From initial bare metal stainless steel stents, the current generations of stents used are predominately covered nitinol stents. The latest randomized control trials reveal that stents decrease the number of interventions required to maintain patency but do not improve the overall access survival. Furthermore, bare metal stents have been shown to be inferior to stent grafts. This review discusses indications for stent deployment in the hemodialysis access, the current evidence for their use, and briefly touches on their complications.


Subject(s)
Aneurysm, False/therapy , Angioplasty/instrumentation , Arteriovenous Shunt, Surgical/adverse effects , Catheterization, Central Venous/adverse effects , Graft Occlusion, Vascular/therapy , Renal Dialysis , Stents , Upper Extremity Deep Vein Thrombosis/therapy , Aneurysm, False/etiology , Aneurysm, False/physiopathology , Angioplasty/adverse effects , Graft Occlusion, Vascular/etiology , Graft Occlusion, Vascular/physiopathology , Humans , Prosthesis Design , Risk Factors , Treatment Outcome , Upper Extremity Deep Vein Thrombosis/etiology , Upper Extremity Deep Vein Thrombosis/physiopathology , Vascular Patency
6.
Clin Transplant ; 31(9)2017 Sep.
Article in English | MEDLINE | ID: mdl-28504869

ABSTRACT

Kidney transplant in patients with liver cirrhosis and nondialysis chronic kidney disease (CKD) is controversial. We report 14 liver cirrhotic patients who had persistently low MDRD-6 estimated glomerular filtration rate (e-GFR) <40 mL/min/1.73 m2 for ≥3 months and underwent either liver transplant alone (LTA; n=9) or simultaneous liver-kidney transplant (SLKT; n=5). Pretransplant, patients with LTA compared with SLKT had lower serum creatinine (2.5±0.73 vs 4.6±0.52 mg/dL, P=.001), higher MDRD-6 e-GFR (21.0±7.2 vs 10.3±2.0 mL/min/1.73 m2 , P=.002), higher 24-hour urine creatinine clearance (34.2±8.8 vs 18.0±2.2 mL/min, P=.002), lower proteinuria (133.2±117.7 vs 663±268.2 mg/24 h, P=.0002), and relatively normal kidney biopsy and ultrasound findings. Post-LTA, the e-GFR (mL/min/1.73 m2 ) increased in all nine patients, with mean e-GFR at 1 month (49.8±8.4), 3 months (49.6±8.7), 6 months (49.8±8.1), 12 months (47.6±9.2), 24 months (47.9±9.1), and 36 months (45.1±7.3) significantly higher compared to pre-LTA e-GFR (P≤.005 at all time points). One patient developed end-stage renal disease 9 years post-LTA and another patient expired 7 years post-LTA. The low e-GFR alone in the absence of other markers or risk factors of CKD should not be an absolute criterion for SLKT in patients with liver cirrhosis.


Subject(s)
End Stage Liver Disease/surgery , Liver Cirrhosis/complications , Liver Transplantation , Renal Insufficiency, Chronic/complications , Adult , Aged , Clinical Decision-Making , End Stage Liver Disease/complications , Female , Follow-Up Studies , Glomerular Filtration Rate , Humans , Liver Cirrhosis/diagnosis , Liver Cirrhosis/physiopathology , Liver Transplantation/methods , Male , Middle Aged , Renal Insufficiency, Chronic/diagnosis , Renal Insufficiency, Chronic/physiopathology , Retrospective Studies , Transplantation, Homologous , Treatment Outcome
8.
Semin Dial ; 30(4): 338-346, 2017 07.
Article in English | MEDLINE | ID: mdl-28523699

ABSTRACT

The placement of a peritoneal dialysis (PD) catheter by interventionalists demands not only procedural skill but also an ability to decipher real-time ultrasonographic and fluoroscopic images. In this article, we discuss how imaging assists in PD placement and recognition of complications. To aid this endeavor, we have provided images and video clips that should assist interventionalists. Compared with the fluoroscopic technique, peritoneoscopic PD catheter placement provides direct visual imaging to also aid placement of the initial trocar and the peritoneal catheter.


Subject(s)
Catheterization, Peripheral , Kidney Failure, Chronic/diagnostic imaging , Kidney Failure, Chronic/therapy , Peritoneal Dialysis , Catheters, Indwelling , Humans , Patient Selection , Radiography , Ultrasonography
9.
Tech Vasc Interv Radiol ; 20(1): 2-8, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28279405

ABSTRACT

Dialysis vascular access management in the United States changed significantly after National Kidney Foundation-Kidney Disease Outcome Quality Initiative (NKF-KDOQI) clinical practice guidelines were first published in 1997. The Centers for Medicare and Medicaid Service adopted these guidelines and in collaboration with the End-Stage Renal Disease Networks established the Fistula First Breakthrough Initiative (FFBI) in 2003 to improve the rate of arteriovenous fistula use over arteriovenous graft and central venous catheter in the dialysis population. The implementation of guidelines and FFBI has led to a significant increase in the arteriovenous fistula use in the prevalent dialysis population. The guidelines are criticized for being opinion based and often impractical. Over the past 2 decades, the patient population undergoing dialysis has become older with complex comorbidities and challenges for creating an ideal vascular access. Advancing knowledge about access pathophysiology, improved treatment options, and improved process of care with team approach model point toward diminishing relevance of few of the existing guidelines. Moreover, several guidelines remain controversial and may be leading to clinical decisions that may be unfavorable to the patients. The review discusses the historical aspect of vascular access care in the United States and evolution of current practice standards and controversies surrounding few of these guidelines in the current time.


Subject(s)
Arteriovenous Shunt, Surgical/standards , Blood Vessel Prosthesis Implantation/standards , Catheterization, Central Venous/standards , Kidney Failure, Chronic/therapy , Practice Guidelines as Topic/standards , Renal Dialysis/standards , Aged , Arteriovenous Shunt, Surgical/adverse effects , Arteriovenous Shunt, Surgical/history , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/history , Catheterization, Central Venous/adverse effects , Catheterization, Central Venous/history , Female , Guideline Adherence/standards , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/epidemiology , Kidney Failure, Chronic/history , Male , Middle Aged , Patient Selection , Practice Patterns, Physicians'/standards , Renal Dialysis/history , Risk Factors , Treatment Outcome , United States/epidemiology
10.
J Vasc Access ; 17(5): 380-5, 2016 Sep 21.
Article in English | MEDLINE | ID: mdl-27373535

ABSTRACT

Stent migration is an inherent complication of stent deployment. A number of factors are responsible for this dreaded complication. The stent may eventually migrate to the heart or lungs or in the process of migration damage structures en route to its final destination. A number of techniques are available to bail out interventionalists if such a situation should arise. Occasionally a wait and watch approach may be prudent.


Subject(s)
Arteriovenous Shunt, Surgical/adverse effects , Blood Vessel Prosthesis Implantation/adverse effects , Device Removal/methods , Endovascular Procedures/adverse effects , Endovascular Procedures/instrumentation , Foreign-Body Migration/therapy , Graft Occlusion, Vascular/therapy , Renal Dialysis , Stents , Adult , Arteriovenous Shunt, Surgical/instrumentation , Blood Vessel Prosthesis , Blood Vessel Prosthesis Implantation/instrumentation , Female , Foreign-Body Migration/etiology , Graft Occlusion, Vascular/etiology , Humans , Male , Risk Factors , Treatment Outcome
11.
Am J Kidney Dis ; 68(2): 312-315, 2016 Aug.
Article in English | MEDLINE | ID: mdl-26857647

ABSTRACT

Interventional nephrologists and radiologists place peritoneal dialysis catheters using the percutaneous fluoroscopic technique in both the inpatient and outpatient setting. Nephrologists caring for such patients may have to diagnose and manage the complications resulting from these procedures. Abdominal pain can occur following peritoneal dialysis catheter placement when the local and systemic analgesia wears off. However, abdominal pain with hypotension is suggestive of a serious complication. Bleeding into the abdomen and perforation of the colon or bladder should be considered in the differential diagnosis. In the case reported here, the peritoneogram showed contrast in the bowel, and correct interpretation by the interventionist would have prevented this complication. The characteristic pattern of peritoneogram images in this case will guide interventionists to avoid this complication, and the discussion of the differential diagnosis and management will assist nephrologists in taking care of such patients.


Subject(s)
Catheterization/adverse effects , Colon, Transverse/injuries , Intestinal Perforation/etiology , Peritoneal Dialysis , Aged , Humans , Male , Peritoneum
12.
Semin Dial ; 28(6): 676-9, 2015.
Article in English | MEDLINE | ID: mdl-26133728

ABSTRACT

Thrombectomy of a clotted upper arm access may be complicated by brachial artery embolization. A number of techniques have been described to relieve the embolization that may not always be successful. Backbleeding is one such technique. We describe a minimal modification that makes backbleeding more effective.


Subject(s)
Arteriovenous Shunt, Surgical/adverse effects , Brachial Artery , Embolectomy/methods , Embolism/surgery , Renal Dialysis/methods , Aged , Embolism/etiology , Humans , Male , Renal Dialysis/adverse effects , Reproducibility of Results
13.
Semin Dial ; 28(5): 533-43, 2015.
Article in English | MEDLINE | ID: mdl-25808428

ABSTRACT

A high-flow access has been defined as one with a flow >1-1.5 l/minute or as one where the access flow is >20% of the cardiac output. Although it may be asymptomatic, it can be associated with cardiopulmonary complications, aneurysms, central vein stenosis and the distal hypoperfusion ischemic syndrome in some patients. The decision for surgical intervention should be made after careful medical optimization especially in patients with high output cardiopulmonary compromise. In this review, we present a summary of current knowledge about the pathophysiology of a high-flow fistula, followed by a concise, comprehensive synopsis of current medical and surgical therapy.


Subject(s)
Arteriovenous Shunt, Surgical/adverse effects , Cardiovascular Diseases/etiology , Kidney Failure, Chronic/therapy , Cardiovascular Diseases/physiopathology , Humans , Regional Blood Flow , Renal Dialysis/adverse effects , Stroke Volume , Vascular Resistance
14.
Hemodial Int ; 19(1): 132-5, 2015 Jan.
Article in English | MEDLINE | ID: mdl-24725377

ABSTRACT

High bilirubin levels are nephrotoxic. Bilirubin can cause a functional proximal tubulopathy or may precipitate into casts associated with acute tubular injury. This condition is known as bile cast nephropathy. The kidney injury is generally reversible if bilirubin levels are decreased early. We present a case wherein an alcoholic patient presented with high bilirubin levels and anuric acute kidney injury. The initial urine analysis suggested intrinsic renal disease. A kidney biopsy, performed a few days after the initiation of dialysis, demonstrated the presence of bile casts along with acute tubular injury. The patient however continued to be dialysis dependent inspite of initiating prednisolone to treat acute alcoholic hepatitis.


Subject(s)
Bile/metabolism , Jaundice/diagnosis , Kidney Diseases/pathology , Adult , Female , Humans
15.
Semin Dial ; 27(6): E57-9, 2014.
Article in English | MEDLINE | ID: mdl-25250769

ABSTRACT

Balloon rupture during angioplasty is an uncommon event. The ruptured balloon usually is removed through its introducer sheath without any problems. However, there may be occasions when a ruptured balloon cannot be withdrawn from an access. We describe a simple technique that can be used to extricate a stuck ruptured angioplasty balloon.


Subject(s)
Angioplasty, Balloon/adverse effects , Angioplasty, Balloon/instrumentation , Device Removal/methods , Equipment Failure , Humans
16.
Semin Dial ; 27(5): 529-32, 2014.
Article in English | MEDLINE | ID: mdl-24438105

ABSTRACT

Stent strut protrusion through the skin is a rare and a potentially dangerous complication from the cannulation of stents placed within arterio-venous fistulas and grafts. Such cases are usually managed surgically. We present a case wherein strut penetration of an arterio-venous fistula was noted at the distal (uncovered) end of a Fluency Plus(®) tracheo bronchial stent graft. After analyzing the various reasons why this may have happened, a nonsurgical approach was taken to preserve the access and manage strut protrusion.


Subject(s)
Arteriovenous Shunt, Surgical , Renal Dialysis , Stents/adverse effects , Aged , Humans , Male , Prosthesis Design , Prosthesis Failure
17.
Semin Dial ; 27(5): 512-7, 2014.
Article in English | MEDLINE | ID: mdl-24397566

ABSTRACT

The general and interventional nephrologist may occasionally encounter a situation where the patient may state that he/she has an allergy to lidocaine or heparin. Heparin hypersensitivity is usually either a delayed type hypersensitivity reaction or an immune-mediated thrombocytopenia. While a number of alternative drugs are available, many of them are subject to local availability, food and drug administration indications, and the patient's hepatic and renal function. Many of these drugs do not have antidotes in case of bleeding. Lidocaine hypersensitivity is usually a delayed type reaction, although adverse reactions, which are much more common, are wrongly labeled as an allergy. 1% diphenhydramine and benzyl alcohol may be used as alternatives.


Subject(s)
Anticoagulants/adverse effects , Drug Hypersensitivity/therapy , Heparin/adverse effects , Hypersensitivity, Delayed/therapy , Hypersensitivity, Immediate/therapy , Lidocaine/adverse effects , Adult , Humans , Hypersensitivity, Delayed/chemically induced , Hypersensitivity, Immediate/chemically induced , Male , Middle Aged , Thrombocytopenia/chemically induced
18.
Semin Dial ; 27(2): E10-20, 2014 Mar.
Article in English | MEDLINE | ID: mdl-23721424

ABSTRACT

The use of stents has become common practice in various interventional fields. The purpose of this article is to provide the interventionalist with an understanding of the basic structure stent. We describe the etymology, the classification and describe various terms used by engineers as they strive to develop that "ideal" stent. We also describe the fabrication process briefly and finally elaborate on the characteristic "build and cut" of some commonly used stents.


Subject(s)
Prosthesis Design , Stents , Endovascular Procedures/instrumentation , Nephrology/instrumentation
19.
Hemodial Int ; 18(1): 212-4, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24015751

ABSTRACT

The dialysis patient is prone to elevations in the calcium phosphorus product and hyperparathyroidism, which contributes to valvular and vascular calcification. We present the case of a young lady on chronic dialysis that developed mitral calcification complicated by severe mitral stenosis, caseous calcification and retinal embolization. She subsequently required mitral valve replacement.


Subject(s)
Calcinosis/etiology , Hyperparathyroidism/therapy , Mitral Valve Stenosis/etiology , Renal Dialysis , Adult , Calcinosis/pathology , Calcinosis/surgery , Female , Humans , Hyperparathyroidism/complications , Mitral Valve Stenosis/pathology , Mitral Valve Stenosis/surgery
20.
Am J Kidney Dis ; 61(6): 984-7, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23403021

ABSTRACT

Many of the tools used in interventional nephrology, such as glidewires and sheaths, are coated with a hydrophilic polymer to increase their lubricity; however, this polymer can shear off, which causes polymer embolization. We describe 3 cases in which polymer emboli were found on histopathologic examination in an arteriovenous graft, a transplanted kidney, and the myocardium. A review of the literature shows that although most of these phenomena are benign, in some patients, it may present with significant morbidity.


Subject(s)
Embolism/etiology , Endovascular Procedures/adverse effects , Foreign-Body Reaction/etiology , Polymers/adverse effects , Aged , Coronary Vessels , Endovascular Procedures/instrumentation , Fatal Outcome , Female , Humans , Male , Middle Aged , Pulmonary Embolism/etiology , Renal Artery Obstruction/etiology
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