[Effect of exogenous testosterone on the excretion of luteinizing and follicle-stimulating hormones in hypogonadism]. / Vliianie ékzogennogo testosterona na ékskretsiiu liuteiniziruiushchego i follikulostimuliruiushchego gormonov u bol'nykh gipogonadizmom.

A study was made of lutropin, follitropin excretion and the effect of testosterone on these parameters in men with hypogonadism. Apart from elevation (primary hypogonadism) and reduction (secondary hypogonadism) of the gonadotropin hormones production, of importance in the mechanism of sexual insufficiency is a change in correlation between luteinizing and follicles-stimulating hormones effects caused by lutropin deficiency or prevalence. Testosterone administered in the given pathology produced a different action on gonadotropin production (an inhibitory, stimulating, or none) depending on the level and intensity of the hypophysis-gonads system affection.

[Urinary excretion of testosterone and androstenedione in hypogonadism in men]. / Vydelenie s mochoi testosterona i androstendiona pri gipogonadizme u muzhchin.

The authors present the results of determination of the testosterone and androstendion excretion in the patients with various forms of hypogonadism and in healthy men. Testosterone excretion was decreased in the patients with hypogonadism, against the background of normal or increased androstendion excretion whereas the degree of deviations of the testosterone/androstendion ratio depended on the clinical variant of hypogonadism. Thus, retarded or decreased accumulation of the enzymes in the testes responsible for the change from the "child" to the "mature" type of steroid biosynthesis could serve as a mechanism of hypogonadism occurrence, which should be taken into consideration in the elaboration of the methods of syndrome therapy of this type of pathology.

[Gonadotropic hormone excretion in men with hypogonadism and its dynamics under the influence of exogenous testosterone]. / Ekskretsiia gonadotrophnykh gormonov pri gipogonadizme u muzchin i ee dinamika pod vliianiem ékzogennogo testosterone

The work is a clinico-laboratory study and and treats of the results of determination of gonadotropine excretion before and after the administration of testosterone to the patients with various forms of hypogonadism. The prevailing effect of testosterone on the excretion of the gonadotropic hormones could be blocking, stimulating or neutral depending on the clinical variant of hypogonadism. Thus, a change of sensitivity of the central link in the hypophysis-gonad system to the action of the peripheral hormones could apparently be of definite significance in the pathogenesis of hypogonadism; this should be taken into consideration in the elaboration of rational schemes of its therapy.

[Excretion of testosterone in men with various forms of hypogonadism]. / Ekskretsiia testosterona u muzhchin s razlichnymi formami gipogonadizma

A reduction of testosterone excretion in men with hypogonadism is reported in literature; however, the clinical peculiarity of its individual forms are not considered in these works. This paper treats of testosterone excretion in 43 patients with various forms of hypogonadism, of this number in 36 before and after a single testosterone-propionate loading. There was seen a reduction of testosterone excretion in hypogonadism. Secondary hypogonadism coursed against the background of a more marked insufficiency of testosterone excretion than the primary one. In a number of hypogonadism cases testosterone excretion remained unchanged and their clinical signs were caused by an inadequate realization of the androgenic effect. In hypogonadism an increase of the urinary excretion following its administration did not always correspond to the dose of the administered hormone, which could serve as one of the pathogenetic mechanisms of development of the disease.