[The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research)]. / Vliianie ékstrakta Rhodiola rosea na chastotu retsidivov poverkhnostnogo raka mochevogo puzyria (éksperimental'no-klinicheskoe issledovanie).

Oral administration of Rhodiola rosea extract to a small group of patents (n = 12) with superficial bladder carcinoma (T1G1-2) improved the characteristics of the urothelial tissue integration, parameters of leukocyte integrins and T-cell immunity. The average frequency of relapses for these patients has been found to fall twice, though statistical differences were not significant.

[Changes in the mechanical integration of transitional epithelial cells and in the immune status of patients with bladder tumors]. / Izmenenie mekhanicheskoi integratsii kletok perekhodnogo épiteliia i immunnogo statusa bol'nykh s opukholiami mochevogo puzyria.

Mutual adhesiveness of urothelial tissue cells have been studied in healthy donors and patients with benign and malignant bladder tumors. The decreased mutual adhesiveness has been shown not only for tumors, but for surrounding urothelial tissue as well. Urothelial tissue integration, T-cell immunity and parameters of leukocyte integrins were affected most of all in bladder tumor stage T2 and T3. Basing on these findings, the authors recommend conservative therapy only in superficial bladder cancer.

[Preventive effect of Rhodiolae rosea in spontaneous liver carcinogenesis in a mice model of high-tumor strain]. / Profilakticheskii éffect Rhodiolae rosea pri spontannom opukholeobrazovanii v pecheni na modeli vysokorakovoi linii myshei.

Different schemes of Rhodiolae rosea usage per os for prophylaxis of mouse hereditary hepatomas have been studied. A long-term effect on stimulation of tissue integration, T-immune activity and sufficient decrease of tumour frequency has been shown for R. rosea usage in early ontogenesis. A short-term effect on tissue and immune parameters has been demonstrated for R. rosea usage in middle ontogenesis. High-tumour frequency (as in the control), but tumour size decrease (comparing to the control) has been noticed in this case. A tendency to synchronic alterations of tissue integration and T-immune activity has been established in these experiments. It can be attributed to the assumption of communication between tissue (local) and immune (common) defence from tumour growth in the organism.

[Testing of plant extracts preparations for prevention and non-toxic therapy of oncologic diseases in experimental models]. / Ispytanie preparatov rastitelnogo proiskhozhdeniia dlia profilaktiki i netoksicheskoi terapii onkologicheskikh zabolevanii na éksperimentalnykh modeliakh.

The extracts from Panax ginseng and Rhodiolae rosea from natural roots, from cultural callus tissue and from Ganoderma mushroom have been studied for adaptogene, T-immunogene activities and for stimulation of mechanical integration in tissues predisposed to hereditary tumors. The least activity has been shown by extracts from Ganoderma M., that from Rhodiolae rosea natural root has turned out to the most effective. This study can serve as the basis for further investigations by using the extracts on inbred mice and in the clinical setting for the prevention and intoxic therapy of tumors.