ABSTRACT
We report a case with epileptic seizures, cognitive dysfunction, livedo reticularis, renal microangiopathy, acute myocardial infarction and high titres of anticentromere antibodies (ACA) and IgG/IgM anticardiolipin antibodies. This is a rare association between primary antiphospholipid syndrome and ACA positivity that has not been reported so far in the literature.
Subject(s)
Antibodies, Anticardiolipin/blood , Antiphospholipid Syndrome/complications , Centromere/immunology , Cognition Disorders/etiology , Epilepsy/etiology , Renal Artery Obstruction/etiology , Adult , Antiphospholipid Syndrome/blood , Cognition Disorders/blood , Epilepsy/blood , Humans , Male , Myocardial Infarction/blood , Myocardial Infarction/etiology , Renal Artery Obstruction/blood , Skin Diseases, Vascular/blood , Skin Diseases, Vascular/etiologyABSTRACT
Papular-purpuric 'gloves and socks' syndrome (PPGSS) has been associated with parvovirus B-19 infection. We report a case of an adult immunocompetent male who presented with PPGSS. Bone marrow examination revealed pure red cell aplasia. Parvovirus B-19 DNA was detected by polymerase chain reaction in the patient's serum, whole blood and in the cutaneous lesions. This report illustrates the variety of clinical manifestations caused by B-19 infection, presents for the first time the concurrent appearance of pure red cell aplasia and PPGSS in the same patient and, finally, suggests that PPGSS may be due to direct lytic effect of the virus.
