[The blood glutathione system in cerebral vascular diseases and its treatment with alpha-lipoic acid].

The changes of glutathione metabolism are rare in dyscirculatory encephalopathy and ischemic stroke (IS) of mild severity. The frequent and considerable changes have been revealed in IS of moderate and high severity as well as in hemorrhagic stroke. An increase of activities of glutathione peroxidase and glutathione transferase is the most typical. The increase of enzyme activity was not observed at the beginning of treatment after 3 days and in patients with severe degree of disease who died later. A standard therapy decreased the quantity and/or expression of changes of the glutathione metabolism in patients with IS of moderate and high severity while the addition of alpha-lipoic acid (alpha-LA) led to the complete normalization in IS of moderate severity and normalization of most parameters in IS of high severity. The increase of functional activity of the glutathione system at the early stage of treatment of IS and the favorable changes during the treatment, in particular after the addition of alpha-LA, were correlated with the improvement of neurological status assessed with the NIHSS. It has been confirmed that the glutathione system plays an important role in the tolerance to brain ischemia.

[Glutathione system in erythrocytes and blood plasma in strokes and dyscirculatory encephalopathy].

In dyscirculatory encephalopathy and moderate ischemic stroke there are single changes of components of glutathione metabolism. In moderate and severe ischemic stroke frequent and considerable changes have been revealed. Changes in hemorrhagic stroke are also expressed. An increase of activities of glutathione peroxidase and glutathione transferase is the most typical, rarely the increase of glutathione reductase and GSH is observed. The increase of enzymes activity was absent at the delayed oneset of treatment (more than 3 days) and in severe cases patients who died later. Glutathione system is important in the tolerance to cerebral ischemia.

[Fluorescent method of studying the binding sites of serum albumin for assessing status of patients with purulent-septic diseases]. / Fliuorestsentnyi metod issledovaniia sviazyvaiushchikh tsentrov syvorotochnogo al'bumina dlia otsenki sostoianiia bol'nykh gnoino-septicheskimi zabolevaniiami.

The concentration and properties of the binding centers of the albumin molecule in blood serum of patients with pyo-septic diseases (peritonitis, pancreatonecrosis and sepsis) were investigated. The patients of this category were shown to have a considerably decreased and greatly variable indices of the general concentration of albumin and of effective concentration of albumin in their blood serum. The fluorescent indices were established to correlate with the severity of the disease, efficiency of treatment, prognosis of the development of the disease and its outcome.