[The dynamics of C-reactive protein in the process of coronary artery bypass grafting in patients with ischemic heart disease].

The article presents the assessment of prognostic value of perioperative level of C-reactive protein in the development of post-operative cardio-vascular complications in patients with ischemic heart disease and underwent coronary artery bypass grafting. The sample consisted of 99 patients with stable forms of ischemic heart disease and underwent the planned coronary artery bypass grafting. The average age of patients was 58 +/- 4.19 years. All patients were applied direct revascularization of myocardium in conditions of artificial blood circulation. The patients were divided on the groups depending on occurrence of post-operational cardio-vascular complications. The group I consisted of 42 patients with non-complicated post-operational period (42%). The group 2 consisted of 57 patients with cardio-vascular complications and included the subgroup of 24 patients with fibrillation of atriums developed in post-operational period. The concentration of C-reactive protein was analyzed in blood serum one day before the operation and at first and seventh days after operation. The post-operative period after application of coronary artery bypass in conditions of ischemic heart disease is characterized by activation of inflammation reaction evaluated by concentration of C-reactive protein. The pre-operation level of C-reactive protein can be used as prognostic marker of development of cardio-vascular complications, post-operative fibrillation of atriums after application of coronary artery bypass in particular

[Relationship between endothelial and erectile functions in patients with coronary heart disease].

The study included 92 men with stable coronary heart disease (CHD) aged 39-61 (mean 55 +/- 5.3) years. Groups 1 and 2 were comprised of 63 patients with erectile dysfunction (ED) and 29 ones without it respectively. It was shown that most patients with CHD suffer ED (68.5%). The probability of ED increases in the presence of such risk factors as diabetes mellitus, multifocal atherosclerosis, disturbances of lipid metabolism. Severity of ED grows with CHD duration and body mass. Parameters of endothelium-dependent dilation of brachial and cavernous arteries were impaired in ED patients which suggests the compromised ability of these vessels to respond to mechanical deformation. ED is a marker not only of functional disturbances of the vascular tone but also of severity of atherosclerotic lesions. Correlation analysis revealed the relationship between mean endothelium-dependent dilation of brachial artery and severity of ED; the latter also correlated with such markers of cardiovascular risk as multifactor atherosclerosis, obesity, and disturbances of lipid metabolism.