[Biochemical bases for the antiseizure role of the pineal gland]. / Biokhimicheskie osnovy protivosudorozhnoi roli pineal'noi zhelezy.

Metabolism of serotonin was studied in pineal gland of Wistar rats with low and high rate of audio excitability as well as in the Krushinsky-Molodkina rat population genetically predisposed to audio-dependent convulsions. Intensive turnover of serotonin via N-acetyl serotonin into melatonin was found in pineal gland of rats insensitive to sensory stimulus, whereas the rate of this response was decreased in the gland tissue of animals sensitive to audio effects as well as inhibition of serotonin turnover into melatonin was noticed in pineal gland of rats predisposed genetically to audio-dependent convulsions.

[Lipid peroxidation in tissues during subliminal electrostimulation of limbic system structures in the brain]. / Protsessy perekisnogo okisleniia lipidov v tkaniakh pri podporogovoi élektrostimuliatsii struktur limbicheskoi sistema mozga.

The experiments on rats have shown that during prolonged subliminal electrostimulation of limbic brain system structures peroxidation is enhanced in the blood and tissues (myocardium, liver, parodontium), with it being realized via activation of sympathoadrenal and hypothalamo-hypophyseal systems and stipulated by the failure of physiologic antioxidative mechanisms.

[The role of mediators in the genesis of convulsive activity. Biogenic monoamine content of the brain of rats with various predispositions to audiogenic convulsions]. / Izuchenie roli mediatorov v formirovanii sudorozhnoi gotovnosti. Soderzhanie biogennykh monoaminov v golovnom mozge krys s razlichnoi predraspolozhennost'iu k audiogennym sudorogam.

Content of serotonin, tryptophane, adrenaline, noradrenaline, dopamine, DOPA and tyrosine in was studied in cerebellum, truncus cerebri, hypothalamus and brain hemispheres of rats with various predisposition to audiogenic convulsions. Distinct decrease in content of brain serotonin, noradrenaline and increase in dopamine content was noted in rats with high level of audiogenic convulsive activity. The data obtained suggest that the increase in dopamine and decrease in serotonin and noradrenaline content in brain tissue may be among the factors responsible for elevation of potential convulsive activity of central nervous system.

[Biogenic monoamines and their precursors in rats with spontaneous arterial hypertension]. / Biogennye monoaminy i ikh predshestvenniki u krys so spontannoi arterial'noi gipertenziei.

Content of tryptophane, tyrosine, serotonin, noradrenaline, adrenaline and dopamine was studied in blood serum and various brain regions of rats with genetically determined spontaneous form of hypertension. The arterial pressure of these animals was shown to depend on activity of noradrenaline-, serotonin- and dopaminergic systems of brain. Oppositely directed alterations in content of dopamine and noradrenaline were observed in various brain regions apparently as a result of changes in activity of the enzymes involved in the amines synthesis and degradation.

[Spectrofluorimetric study of interaction between acetylcholine and brain proteins]. / Spektrofluorimetricheskoe iccledovanie vzaimodeistviia atsetilkholina s belkami mozga.

Interaction of acetyl-choline in 10(-4) . 10(-12) M concentration with a water-soluble fraction of homogenates of different brain areas (medulla oblongata, pons varolii, sensomotor cortex, dorsal and ventral hippocamp, hypothalamus, amygdaloid nuclei region and septal region) was studied by the spectrofluorimetric method. Fluorescence complexes spectra at excitation wavelength of 280, 296 nm were investigated. It is shown that the ACH addition to the water-soluble fractions results in reduction of the spectrum intensity and in insignificant shift of the fluorescence maxima to a short-wave region. This effect is supposed to be due to ACH interaction with the cholinoreceptor (CHR). The number of CHR in all the brain regions studied is calculated. Good correlation is observed between the regional distribution of CHR and the acetylcholinesterase activity.

[Role of the acetylcholine--cholinesterase system in the development of epilepsy]. / O roli sistemy atsetilkholin--kholinésteraza v razvitii épilepsii.

The report pertains to some data on the cholinesterase activity in the blood serum and CSF of 62 patients with epilepsy, in correlation with different clinical characteristics (the severity of the disease, the character of the EEG, frequency of seizures, treatment efficacy, etc). In 86,8% of the cases there was a significant increase in the activity of serum cholinesterase. Increased cholinesterase activity correlated only with pronounced pathological changes in the EEG (reverse correlation) and the efficacy of treatment (direct correlation). After surgical treatment of 9 cases there was a drop in the cholinesterase activity of the blood serum and CSF, which correlated with an improvement in the general state of the patients. On the basis of personal experience, as well as literary data, it is assumed that an increase in the cholinesterase activity in epileptic patients is not related to the main etiological factors of this disease but is rather a secondary change, a peculiar "symptom" of the disease.