1.
Acta Microbiol Bulg
; 30: 37-40, 1993.
Article
in English
| MEDLINE
| ID: mdl-8285131
ABSTRACT
The synergistic effect shown by the combination of a natural product, polyphenolic complex (PC) isolated from Geranium sanguineum L., and rimantadine (R) in vitro and in ovo [7], encouraged us to continue these studies by in vivo testing. A marked protective effect in experimental influenza virus A (H3N2) infection in mice was found when PC was applied nasally (i.n.) (1.0 mg/kg) only once 6 h before infection in combination with R applied orally in concentration 10.5 and 2.5 mg/kg 2h before and 2.24 and 48 h after viral inoculation (PI = 72.55%, 55% and 57.8% respectively).
Subject(s)
Antiviral Agents/therapeutic use , Flavonoids , Influenza A virus , Orthomyxoviridae Infections/drug therapy , Phenols/therapeutic use , Plant Extracts/therapeutic use , Polymers/therapeutic use , Rimantadine/therapeutic use , Animals , Drug Evaluation, Preclinical , Drug Synergism , Drug Therapy, Combination , Influenza A virus/drug effects , Mice , Polyphenols , Time Factors
2.
Acta Microbiol Bulg
; 22: 16-21, 1988.
Article
in Bulgarian
| MEDLINE
| ID: mdl-3247856
Subject(s)
Antiviral Agents/pharmacology , Flavonoids , Influenza A virus/drug effects , Influenza B virus/drug effects , Phenols/pharmacology , Plants, Medicinal , Polymers/pharmacology , Virus Replication/drug effects , Antiviral Agents/isolation & purification , Depression, Chemical , Dose-Response Relationship, Drug , Hemagglutination, Viral/drug effects , Influenza A virus/physiology , Influenza B virus/physiology , Phenols/isolation & purification , Polymers/isolation & purification , Polyphenols , Time Factors , Virus Cultivation
3.
Acta Microbiol Bulg
; 21: 66-71, 1987.
Article
in Bulgarian
| MEDLINE
| ID: mdl-3439494
4.
Acta Microbiol Bulg
; 19: 18-22, 1986.
Article
in Bulgarian
| MEDLINE
| ID: mdl-3565089
Subject(s)
Adamantane/analogs & derivatives , Antiviral Agents/therapeutic use , Flavonoids , Orthomyxoviridae Infections/drug therapy , Phenols/therapeutic use , Plants, Medicinal , Polymers/therapeutic use , Rimantadine/therapeutic use , Animals , Chick Embryo , Culture Techniques , Drug Evaluation, Preclinical , Drug Therapy, Combination , Influenza A virus/drug effects , Orthomyxoviridae Infections/microbiology , Polyphenols , Virus Replication/drug effects
5.
Acta Microbiol Bulg
; 18: 73-7, 1986.
Article
in Bulgarian
| MEDLINE
| ID: mdl-3776704
Subject(s)
Antiviral Agents/pharmacology , Flavonoids , Influenza A virus/drug effects , Phenols/pharmacology , Plants, Medicinal , Polymers/pharmacology , Virus Replication/drug effects , Animals , Antiviral Agents/isolation & purification , Antiviral Agents/therapeutic use , Chick Embryo , Depression, Chemical , Drug Evaluation, Preclinical , Influenza A virus/physiology , Mice , Mice, Inbred ICR , Orthomyxoviridae Infections/drug therapy , Phenols/isolation & purification , Phenols/therapeutic use , Polymers/isolation & purification , Polymers/therapeutic use , Polyphenols
6.
Acta Microbiol Bulg
; 18: 78-82, 1986.
Article
in Bulgarian
| MEDLINE
| ID: mdl-3776705
Subject(s)
Antiviral Agents/pharmacology , Flavonoids , Influenza A virus/drug effects , Influenza B virus/drug effects , Phenols/pharmacology , Plants, Medicinal , Polymers/pharmacology , Virus Activation/drug effects , Animals , Antiviral Agents/isolation & purification , Antiviral Agents/therapeutic use , Chick Embryo , Depression, Chemical , Drug Evaluation, Preclinical , Influenza A virus/growth & development , Influenza B virus/growth & development , Mice , Mice, Inbred ICR , Orthomyxoviridae Infections/prevention & control , Phenols/isolation & purification , Phenols/therapeutic use , Polymers/isolation & purification , Polymers/therapeutic use , Polyphenols
7.
Acta Microbiol Bulg
; 17: 79-85, 1985.
Article
in Bulgarian
| MEDLINE
| ID: mdl-3834770
Subject(s)
Antiviral Agents/pharmacology , Propolis/pharmacology , Resins, Plant/pharmacology , Animals , Antiviral Agents/therapeutic use , Chick Embryo , Drug Evaluation, Preclinical , Influenza A virus/drug effects , Influenza B virus/drug effects , Mice , Microbial Sensitivity Tests , Newcastle disease virus/drug effects , Orthomyxoviridae Infections/drug therapy , Propolis/therapeutic use , Vaccinia virus/drug effects , Virus Replication/drug effects
8.
Acta Microbiol Bulg
; 3: 44-9, 1979.
Article
in Bulgarian
| MEDLINE
| ID: mdl-517169
9.
Acta Microbiol Bulg
; 1: 82-9, 1978.
Article
in Bulgarian
| MEDLINE
| ID: mdl-218429
10.
Acta Microbiol Virol Immunol (Sofiia)
; 2: 77-82, 1975.
Article
in Bulgarian
| MEDLINE
| ID: mdl-1240723
11.
Acta Microbiol Virol Immunol (Sofiia)
; 2: 73-6, 1975.
Article
in Bulgarian
| MEDLINE
| ID: mdl-1217544