Subject(s)
Microwaves , Muscles/radiation effects , Nerve Tissue/radiation effects , Adaptation, Physiological/physiology , Adaptation, Physiological/radiation effects , Animals , Electric Stimulation/methods , In Vitro Techniques , Muscles/physiology , Nerve Tissue/physiology , Neuromuscular Junction/physiology , Neuromuscular Junction/radiation effects , Rana ridibundaABSTRACT
The experiments on edible frogs have revealed the relationship between the effect of sodium chloride, skin potential difference and micro-components iodide and bromide present in the solution. The results obtained furnish the additional information on the synergistic action of mineral water iodide and bromide on the body. Iodide ions were found to act mainly through inhibition of sodium channels of cellular membranes, while bromide ions are likely to affect Na, K-ATPase.
Subject(s)
Bromides/pharmacology , Iodides/pharmacology , Mineral Waters , Skin/drug effects , Animals , Drug Synergism , In Vitro Techniques , Isotonic Solutions , Male , Membrane Potentials/drug effects , Membrane Potentials/physiology , Rana ridibunda , Ringer's Solution , Skin/cytology , Skin Physiological Phenomena , Sodium Chloride/pharmacology , SolutionsABSTRACT
For human skin transcutaneous transport of I ions in vitro depends on sodium chloride-iodide concentration relations in mineral water, whereas such transport for Br ions in mainly determined by absolute concentration of sodium chloride. Optimal proportions of the salts have been specified for I and Br ions transcutaneous transport in definite concentration range. An unknown feature of the mechanism of action of hypertonic salt solutions on ionic skin permeability has been identified. The results are analyzed from the point of view of the ion pairs conception.