ABSTRACT
El 25% de las metástasis de la órbita suelen ser de origen primario desconocido y requieren confirmación histopatológica e inmunohistoquímica. La toma de biopsia con aspiración con aguja fina de la órbita es un procedimiento alternativo a la orbitotomía convencional. Describimos el caso de una mujer de 60 años que presenta una masa tumoral en la órbita derecha y lesiones neoformativas en el cerebro y el cráneo. Incidentalmente, la paciente presentó un trombo en la aurícula izquierda, por lo que se desestimó la orbitotomía y se realizó la biopsia con aspiración con aguja fina de la órbita guiada por ultrasonido con evaluación rápida in situ de las muestras obtenidas. Se encontraron células malignas de adenocarcinoma pulmonar confirmadas con inmunohistoquímica e imágenes diagnósticas del tórax. En conclusión, las muestras obtenidas por biopsia con aspiración con aguja fina de la órbita, junto con el análisis citopatológico e inmunohistológico, permitieron identificar la metástasis orbitaria en el caso mencionado, siendo este procedimiento una alternativa segura, efectiva y mínimamente invasiva
Twenty five percent of orbital metastasis is usually of unknown primary origin and it requires histopathological and immunohistochemical confirmation. The fine-needle aspiration biopsy of the orbit is an alternative procedure to conventional orbitotomy. The case is presented of a 60 year-old woman with a right orbit tumour mass and neoplastic lesions in her brain and cranium. As an incidental finding, she had a thrombus in her left atrium, and so an orbitotomy procedure was ruled out. An ultrasound-guided fine-needle aspiration biopsy was performed instead with rapid on-site evaluation of biopsy samples. These showed malignant cells of a lung adenocarcinoma, which was confirmed with immunohistochemistry and chest diagnostic images. In conclusion, biopsy samples obtained by fine-needle aspiration biopsy, together with cytopathological and immunohistological analysis, enabled orbital metastasis to be identified in the case described, and showed that fine-needle aspiration biopsy is a safe, effective, and minimally invasive alternative
Subject(s)
Humans , Female , Middle Aged , Adenocarcinoma/secondary , Endoscopic Ultrasound-Guided Fine Needle Aspiration , Lung Neoplasms/pathology , Orbital Neoplasms/secondary , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/pathology , Orbital Neoplasms/diagnostic imaging , Orbital Neoplasms/pathologyABSTRACT
Twenty five percent of orbital metastasis is usually of unknown primary origin and it requires histopathological and immunohistochemical confirmation. The fine-needle aspiration biopsy of the orbit is an alternative procedure to conventional orbitotomy. The case is presented of a 60 year-old woman with a right orbit tumour mass and neoplastic lesions in her brain and cranium. As an incidental finding, she had a thrombus in her left atrium, and so an orbitotomy procedure was ruled out. An ultrasound-guided fine-needle aspiration biopsy was performed instead with rapid on-site evaluation of biopsy samples. These showed malignant cells of a lung adenocarcinoma, which was confirmed with immunohistochemistry and chest diagnostic images. In conclusion, biopsy samples obtained by fine-needle aspiration biopsy, together with cytopathological and immunohistological analysis, enabled orbital metastasis to be identified in the case described, and showed that fine-needle aspiration biopsy is a safe, effective, and minimally invasive alternative.
Subject(s)
Adenocarcinoma/secondary , Endoscopic Ultrasound-Guided Fine Needle Aspiration , Lung Neoplasms/pathology , Orbital Neoplasms/secondary , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/pathology , Female , Humans , Middle Aged , Orbital Neoplasms/diagnostic imaging , Orbital Neoplasms/pathologyABSTRACT
Caso clínico: Paciente varón de 35 años con antecedente de infección por VIH, caracterizado por tumoración de crecimiento progresivo en conjuntiva bulbar de ojo izquierdo correspondiente a un carcinoma conjuntival de células escamosas que responde a tratamiento con interferón alfa-2a. Discusión: A nivel conjuntival, el interferón alfa-2b tópico ha sido utilizado como tratamiento inmunomodulador, con el que se observó remisión completa de las neoplasias epiteliales; sin embargo, no se ha publicado el uso del interferón alfa-2a para el tratamiento de carcinoma conjuntival de células escamosas, el cual difiere del intererón alfa-2b en un solo aminoácido (AU)
Case report: A 35 year-old male patient with a history of HIV infection characterized by progressive tumour growth in bulbar conjunctiva of the left eye, corresponding to conjunctival squamous cell carcinoma that responded to treatment with interferon alpha-2a. Discussion: Interferon alpha-2b has been used at conjunctival level as a topical immunomodulator treatment, with complete remission of epithelial neoplasms being observed. However, there have not been any previous publications on the use of interferon alpha-2a, which differs from interferon alpha-2b in a single amino acid, for the treatment of conjunctival squamous cell carcinoma (AU)
Subject(s)
Humans , Male , Adult , Conjunctival Neoplasms/drug therapy , Interferon-alpha/therapeutic use , Carcinoma, Squamous Cell/drug therapy , HIV Infections/complicationsABSTRACT
CASE REPORT: A 35 year-old male patient with a history of HIV infection characterized by progressive tumour growth in bulbar conjunctiva of the left eye, corresponding to conjunctival squamous cell carcinoma that responded to treatment with interferon alpha-2a. DISCUSSION: Interferon alpha-2b has been used at conjunctival level as a topical immunomodulator treatment, with complete remission of epithelial neoplasms being observed. However, there have not been any previous publications on the use of interferon alpha-2a, which differs from interferon alpha-2b in a single amino acid, for the treatment of conjunctival squamous cell carcinoma.
