ABSTRACT
We report the case of a patient with an incidental diagnosis of gallbladder adenocarcinoma with chondrosarcomatoid areas in a cholecystectomy specimen. Since it is associated with a worse prognosis when compared to usual carcinoma, we need to understand this entity to offer our patients a better treatment.
Subject(s)
Adenocarcinoma , Carcinosarcoma , Gallbladder Neoplasms , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/surgery , Carcinosarcoma/pathology , Cholecystectomy , Gallbladder , Gallbladder Neoplasms/diagnostic imaging , Gallbladder Neoplasms/surgery , Humans , Incidental FindingsABSTRACT
El tumor fibroso solitario es una neoplasia mesenquimal de localización tiroidea muy poco usual. Comunicamos el caso de un varón de 42 años con resección del lóbulo tiroideo derecho tras un diagnóstico citológico de proliferación folicular. Macroscópicamente la lesión correspondía a un nódulo encapsulado de 2,5 cm de diámetro máximo. Histológicamente la lesión estaba constituida por una proliferación de células fusiformes que engloban y atrapan a los folículos tiroideos, positivas para vimentina, CD34 y BCL2. El estudio ultraestructural confirmó la naturaleza miofibroblástica de las células neoplásicas (AU)
The thyroid gland is an unusual location for solitary fibrous tumours. We report a case of a 42 year old male with a cytological diagnosis of follicular proliferation. Macroscopically the lesion corresponded to an encapsulated nodule of 2.5 cm. Histologically, it showed a proliferation of spindle cells encompassing thyroid follicles, positive for vimentin, CD34 and BCL2. The ultrastructural study confirmed the myofibroblastic nature of the proliferative cells (AU)
Subject(s)
Humans , Male , Adult , Thyroid Neoplasms/diagnosis , Thyroid Neoplasms/pathology , Neoplasms, Fibrous Tissue/pathology , Thyroid Gland/pathology , Chondrosarcoma, Mesenchymal/pathologySubject(s)
Humans , Female , Middle Aged , Urinary Bladder Fistula/diagnosis , Urinary Bladder Fistula/surgery , Intestinal Obstruction/complications , Intestinal Obstruction/diagnosis , Crohn Disease/complications , Crohn Disease/diagnosis , Endometriosis/complications , Endometriosis/diagnosis , Urinary Bladder Fistula/physiopathology , Urinary Bladder Fistula , Tomography, Emission-Computed/methods , Tomography, Emission-Computed , Abdominal Pain/diagnosis , Abdominal Pain/etiologyABSTRACT
BACKGROUND: Primary papillary serous carcinoma (PPSC) of the peritoneum is a rare neoplasm, histologically indistinguishable from papillary serous carcinoma of the ovary, which diffusely involves the peritoneum but spares or minimally invades the ovaries. To the best of our knowledge, the preoperative and the fine needle aspiration diagnosis of this disorder have not been reported before. CASE: A woman developed an extensive peritoneal neoplasm 4 years after hysterectomy and bilateral salpingo-oophorectomy for benign disease. Fine needle aspiration of the tumor was performed, and the cytologic and immunocytochemical findings were consistent with papillary serous carcinoma. A diagnosis of PPSC of the peritoneum was rendered because review of all slides from previous surgical specimens showed no evidence of carcinoma and no other primary tumors were found elsewhere. CONCLUSION: Fine needle aspiration cytology coupled with immunocytochemical and clinical data allows an unequivocal preoperative diagnosis of papillary serous carcinoma (primary peritoneal or with an ovarian origin). The sole limitation to establish a primary peritoneal origin before surgery is the requirement to histologically study the ovaries. Based on this fact, the preoperative fine needle aspiration cytology diagnosis of PSCP should be restricted to oophorectomized patients.
Subject(s)
Cystadenocarcinoma, Papillary/diagnosis , Cystadenocarcinoma, Serous/diagnosis , Ovarian Neoplasms/diagnosis , Peritoneal Neoplasms/diagnosis , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Ascites/etiology , Biomarkers, Tumor/analysis , Biomarkers, Tumor/biosynthesis , Biopsy, Fine-Needle/methods , Cystadenocarcinoma, Papillary/drug therapy , Cystadenocarcinoma, Papillary/physiopathology , Cystadenocarcinoma, Serous/drug therapy , Cystadenocarcinoma, Serous/physiopathology , Diagnosis, Differential , Female , Humans , Hysterectomy , Immunohistochemistry/methods , Middle Aged , Ovarian Neoplasms/drug therapy , Ovarian Neoplasms/physiopathology , Peritoneal Neoplasms/drug therapy , Peritoneal Neoplasms/physiopathology , Pleural Effusion, Malignant/etiology , Pleural Effusion, Malignant/pathology , Predictive Value of Tests , Treatment OutcomeABSTRACT
OBJECTIVE: To evaluate light microscopic examination of lymph node fine needle aspiration biopsy (FNAB) in order to determine the indications for ancillary procedures and biopsy. STUDY DESIGN: Reports and smears from 693 consecutive lymph node FNABs were reviewed. Fifty-five cases were excluded because of inadequacy of the material, and another 26 were excluded because follow-up information was not available. RESULTS: Cytologically, 220 cases were diagnosed as positive for malignancy and 392 as negative. Global sensitivity was 94.1% and specificity 96.9%. Sensitivity was higher for nonlymphoid neoplasms (98.2%) than for lymphoproliferative disorders (82.8%). CONCLUSION: Lymph node FNAB is a cost-effective procedure, and with adequate cytologic examination and follow-up, a large number of biopsies and time-consuming ancillary techniques can be avoided.
