ABSTRACT
Androgenic alopecia (AGA) is the most prevalent type of progressive hair loss and has psychological repercussions. Nevertheless, the effectiveness of current pharmacological treatments remains limited, in part because the molecular basis of the disease has not been fully elucidated. Our group previously highlighted the important roles of aromatase and 5α-reductase (5α-R) in alopecia in young women with female pattern hair loss. Additionally, an association has been proposed between AGA and prostate cancer (PCa), suggesting that genes implicated in PCa would also be involved in AGA. A low-invasive, sensitive, and precise method was used to determine mRNA levels of aromatase, 5α-R isozymes, and 84 PCa-related genes in samples of plucked hair from young men with AGA and controls. Samples were obtained with a trichogram from the vertex scalp, and mRNA levels were quantified using real-time RT-PCR. The men with AGA had significantly higher 5α-R2 mRNA levels in comparison to controls; interestingly, some of them also showed markedly elevated mRNA levels of 5α-R1 or 5α-R3 or of both, which may explain the varied response to 5α-R inhibitor treatments. The men with AGA also showed significant changes versus controls in 6 out of the 84 genes implicated in PCa. This study contributes greater knowledge of the molecular bases of AGA, facilitating early selection of the most appropriate pharmacological therapy and opening the way to novel treatments.
Subject(s)
Cholestenone 5 alpha-Reductase , Prostatic Neoplasms , Male , Humans , Cholestenone 5 alpha-Reductase/genetics , Aromatase/genetics , Isoenzymes/therapeutic use , RNA, Messenger/genetics , Hair , Alopecia/genetics , Alopecia/drug therapy , Prostatic Neoplasms/geneticsABSTRACT
BACKGROUND: Folliculitis decalvans (FD) is a rare neutrophilic cicatricial alopecia that poses a therapeutic challenge. OBJECTIVES: To describe the therapeutic response in a large number of cases of FD with long-term follow-up and analyze potential prognostic factors associated with severity of form and with a better therapeutic response. METHODS: This multicenter prospective study included patients with FD who had a minimum of 5 years of follow-up. Severity was assessed by the maximum diameter of the cicatricial area. Therapeutic response was evaluated according to stabilization of the size of the cicatricial areas and the improvement in clinical symptoms. RESULTS: A total of 60 patients (37 men [61.7%] and 23 women [38.3%]) with a mean age of 40 years were included. Earlier age of onset (P = .01) was statistically associated with severity of form. Treatment with rifampicin and clindamycin, tetracyclines, and intralesional steroids was the most effective. No statistically significant prognostic factors predicting a better therapeutic response were found. LIMITATIONS: Because FD is a rare disease, the main limitation was the sample size. CONCLUSIONS: An earlier age of onset was associated with the severe form of the disease. The proposed specific therapeutic protocol can be a very useful tool in clinical dermatologic practice.
Subject(s)
Alopecia/pathology , Folliculitis/drug therapy , Folliculitis/pathology , Scalp Dermatoses/drug therapy , Scalp Dermatoses/pathology , Adrenal Cortex Hormones/therapeutic use , Alopecia/drug therapy , Alopecia/etiology , Anti-Bacterial Agents/therapeutic use , Cicatrix/drug therapy , Cicatrix/pathology , Cohort Studies , Combined Modality Therapy , Female , Folliculitis/complications , Follow-Up Studies , Humans , Isotretinoin/therapeutic use , Male , Minoxidil/therapeutic use , Multivariate Analysis , Photochemotherapy/methods , Retrospective Studies , Risk Assessment , Scalp Dermatoses/complications , Spain , Time Factors , Treatment OutcomeSubject(s)
Cellulitis/pathology , Hair/pathology , Scalp Dermatoses/pathology , Skin Diseases, Genetic/pathology , Adolescent , Adult , Chronic Disease , Dermoscopy , Female , Humans , Male , Middle Aged , Retrospective Studies , Young AdultSubject(s)
Alopecia/classification , Alopecia/pathology , Dermoscopy/methods , Alopecia/diagnosis , Biopsy/methods , Female , Humans , Lichen Planus , Retrospective StudiesABSTRACT
BACKGROUND: To our knowledge, there are no large multicenter studies concerning frontal fibrosing alopecia (FFA) that could give clues about its pathogenesis and best treatment. OBJECTIVE: We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA. METHODS: This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline. RESULTS: In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%). LIMITATIONS: The retrospective design is a limitation. CONCLUSIONS: Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
Subject(s)
Alopecia/drug therapy , Alopecia/pathology , Azasteroids/therapeutic use , Finasteride/therapeutic use , Adult , Age Distribution , Aged , Aged, 80 and over , Alopecia/epidemiology , Biopsy, Needle , Cohort Studies , Dutasteride , Female , Fibrosis/epidemiology , Fibrosis/pathology , Forehead , Humans , Immunohistochemistry , Male , Middle Aged , Multivariate Analysis , Postmenopause/physiology , Retrospective Studies , Risk Assessment , Severity of Illness Index , Sex Distribution , Spain/epidemiology , Treatment Outcome , Young AdultSubject(s)
Dermoscopy/trends , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adolescent , Child , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Male , Reproducibility of ResultsSubject(s)
Giant Cell Arteritis/complications , Giant Cell Arteritis/diagnosis , Scalp/pathology , Aged, 80 and over , Anti-Inflammatory Agents/administration & dosage , Debridement , Giant Cell Arteritis/drug therapy , Giant Cell Arteritis/pathology , Humans , Male , Methylprednisolone/administration & dosage , Necrosis , Scalp/surgeryABSTRACT
We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.
Subject(s)
Antineoplastic Agents/adverse effects , Interferon-alpha/adverse effects , Melanoma/drug therapy , Necrosis/chemically induced , Skin Neoplasms/drug therapy , Skin/pathology , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Antineoplastic Agents/administration & dosage , Arm , Chemotherapy, Adjuvant , Debridement , Follow-Up Studies , Humans , Injections, Intravenous , Interferon alpha-2 , Interferon-alpha/administration & dosage , Male , Melanoma/pathology , Melanoma/surgery , Middle Aged , Necrosis/pathology , Ointments , Recombinant Proteins , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Skin Ulcer/chemically induced , Skin Ulcer/drug therapy , Skin Ulcer/surgery , Time FactorsABSTRACT
Presentamos el caso de un varón de 55 años con un melanoma en la región retroauricular derecha que después de un tratamiento quirúrgico y adyuvante con interferón (IFN alfa 2b) según la pauta propuesta por Kirkwood presentó, en el último mes de tratamiento, una necrosis cutánea sólo en uno de los sitios de inyección. La aparición de necrosis cutánea es una situación rara que se ha descrito en pacientes tratados con distintos tipos de IFN
We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN
Subject(s)
Male , Middle Aged , Humans , Interferon-alpha/adverse effects , Necrosis/complications , Necrosis/diagnosis , Necrosis/therapy , Melanoma/complications , Melanoma/diagnosis , Melanoma/therapy , Chemotherapy, Adjuvant , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/therapy , Interleukin-1/analysis , Thrombophilia/diagnosis , Thrombophilia/therapy , Interferons/adverse effectsABSTRACT
No disponible
Subject(s)
Female , Child, Preschool , Humans , Lichen Sclerosus et Atrophicus/drug therapy , Vulvar Diseases/drug therapy , Tacrolimus/therapeutic use , Clobetasol/therapeutic useABSTRACT
Traumatic or amputation neuromas are benign tumours formed by a proliferation of Schwann cells, axons and connective tissue elements. They are secondary to the partial or total section of a nerve pathway due to an accidental or surgical trauma. They can form at any site and affect any type of nerve. The presence of amputation neuromas is very frequent in major surgery but rare in simple excisions of skin tumours. We report two cases with neuroma localized in the neck, one after lymph node dissection for melanoma metastasis and the other after excision of a cutaneous melanoma with 3-cm margin on lateral neck. In both cases, the presence of the neuroma mandated a surgical excision to rule out a possible recurrence of melanoma.
Subject(s)
Head and Neck Neoplasms/pathology , Neoplasms, Second Primary/pathology , Neuroma/pathology , Adult , Female , Humans , Male , Melanoma/surgery , Skin Neoplasms/surgeryABSTRACT
No disponible
