Assessment of Nutrient Levels Provided by General Hospital Patient Menus: A Cross-Sectional Study Carried Out in the Region of Murcia (Spain).

Disease-related malnutrition remains a health problem with a high prevalence that increases the risk of poor patient outcomes, in addition to an elevation of healthcare costs. The aim of this study was to evaluate the nutritional quality of the menus at Ribera Molina Hospital, including their adequacy regarding recommended daily nutrient intakes and the agreement with the theoretical nutrition information provided by catering. The mean levels of energy, macronutrients, vitamins, and minerals provided by the basal, diabetic, and soft diets were calculated through the weighing of plated food served throughout the first 14 days of February 2020. A nutritional overestimation was seen in the nutrition information provided by the catering compared to the values derived from weighing foods (p < 0.01). Despite this, the nutritional content calculated by weighing satisfied the energy and protein requirements of 203 hospitalized patients previously studied in the internal medicine area of the hospital. The mean age of these patients was 62 years, and the main causes of admission were lung, cardiovascular, renal, and digestive diseases. There seems to be an insufficient amount of vitamins E and D, as well as magnesium, on all the menus. A possible insufficient amount of calcium, potassium, zinc, and copper was observed in some of the menus studied. It is necessary to update the hospital prescription manual so the nutritional contents of the diets are accurate and based on the weighted and calculated values to improve the adequacy of diets prescribed to patients.

A Systematic Review of Clinical Trials on the Efficacy and Safety of CRLX101 Cyclodextrin-Based Nanomedicine for Cancer Treatment.

CRLX101 is a cyclodextrin-based nanopharmaceutical designed to improve the delivery and efficacy of the anti-cancer drug camptothecin. Cyclodextrins have unique properties that can enhance drug solubility, stability, and bioavailability, making them an attractive option for drug delivery. The use of cyclodextrin-based nanoparticles can potentially reduce toxicity and increase the therapeutic index compared to conventional chemotherapy. CRLX101 has shown promise in preclinical studies, demonstrating enhanced tumor targeting and prolonged drug release. This systematic review followed PRISMA guidelines, assessing the efficacy and toxicity of CRLX101 in cancer treatment using clinical trials. Studies from January 2010 to April 2023 were searched in PubMed, Scopus, Web of Science, and Cochrane Database of Systematic Reviews, using specific search terms. The risk of bias was assessed using ROBINS-I and Cochrane risk-of-bias tools. After screening 6018 articles, 9 were included in the final review. These studies, conducted between 2013 and 2022, focused on patients with advanced or metastatic cancer resistant to standard therapies. CRLX101 was often combined with other therapeutic agents, resulting in improvements such as increased progression-free survival and clinical benefit rates. Toxicity was generally manageable, with common adverse events including fatigue, nausea, and anemia.

Phase Angle, Handgrip Strength, and Other Indicators of Nutritional Status in Cancer Patients Undergoing Different Nutritional Strategies: A Systematic Review and Meta-Analysis.

Malnutrition in cancer patients is one of the most influential factors in the evolution and mortality of such patients. To reduce the incidence of malnutrition, it is necessary to establish a correct nutritional intervention. For this purpose, precise tools and indicators must be developed to determine the patient's condition. The main objective of this systematic review and meta-analysis was to analyze the relationship between different nutritional strategies, phase angle (PA), and handgrip strength in patients with cancer, with the secondary objectives being the modification of other indicators of nutritional status, such as weight and body mass index (BMI). A systematic review of randomized clinical trials was carried out in March 2023 in the databases PubMed, Web of Science, Cochrane, and Scopus. As a risk-of-bias tool, RoB 2.0 was utilized. A total of 8 studies with a total of 606 participants were included in the analysis. A significant increase in PA was observed after the different nutritional strategies (SMD: 0.43; 95% CI: 0.10 to 0.77; p = 0.01; I2 = 65.63%), also detecting a significant increase in handgrip strength (SMD: 0.27, 95% CI: 0.08 to 0.47; p = 0.01; I2 = 30.70%). A significant increase in PA and handgrip were observed in cancer patients subjected to different nutritional strategies. These results suggest that these indicators could be used in the nutritional and functional assessment of the patients.

Gingivitis como primer síntoma de leucemia aguda mieloblástica / Gingivitis as a first symptom of acute myeloblastic leukemia

Las enfermedades hematológicas, entre ellas la leucemia aguda, pueden manifestarse al diagnóstico con afectación a nivel oral. Las leucemias agudas suponen casi el 10 % de todas las neoplasias. En adultos es más frecuente la leucemia aguda mieloide. Los síntomas son secundarios a las citopenias, así como a la infiltración de diferentes órganos. Debido a que se trata de neoplasias agresivas, el diagnóstico precoz es clave para instaurar el tratamiento lo antes posible, por lo que debemos considerar estas patologías en el diagnóstico diferencial ante la presencia de cuadros febriles de larga evolución o de signos de alarma de las mismas

Hematologic disorders, including acute leukemia, may present oral manifestations as initial evidence of the disease. Acute leukemia represents almost 10% of all types of neoplasia. Acute myeloid leukemia is more frequent in adults. Symptoms are secondary to cytopenias and to infiltration of different organs. Since these are aggressive malignancies, early diagnosis is key to establishing a treatment as soon as possible. We should thus consider these disorders in differential diagnosis when we detect the presence of long-standing fever or other warning signs

Optimization of a method for preparing solid complexes of essential clove oil with ß-cyclodextrins.

BACKGROUND: Clove oil (CO) is an aromatic oily liquid used in the food, cosmetics and pharmaceutical industries for its functional properties. However, its disadvantages of pungent taste, volatility, light sensitivity and poor water solubility can be solved by applying microencapsulation or complexation techniques. RESULTS: Essential CO was successfully solubilized in aqueous solution by forming inclusion complexes with ß-cyclodextrins (ß-CDs). Moreover, phase solubility studies demonstrated that essential CO also forms insoluble complexes with ß-CDs. Based on these results, essential CO-ß-CD solid complexes were prepared by the novel approach of microwave irradiation (MWI), followed by three different drying methods: vacuum oven drying (VO), freeze-drying (FD) or spray-drying (SD). FD was the best option for drying the CO-ß-CD solid complexes, followed by VO and SD. CONCLUSION: MWI can be used efficiently to prepare essential CO-ß-CD complexes with good yield on an industrial scale. © 2016 Society of Chemical Industry.

Use of cyclodextrins to recover catechin and epicatechin from red grape pomace.

The capacity of cyclodextrins (CDs) to extract phenolic compounds from grape pomace was evaluated and compared with that of ethanol/water or aqueous extraction. The extraction method (stirring and ultrasound), temperature and time were also studied. Total phenolic compounds (TPC) and antioxidant activity were measured, and HPLC analysis was used to identify the phenolic compounds. The extracts obtained using the ethanol/water mixture presented the highest TPC content and antioxidant activity, followed by those obtained using CD solutions. The addition of CDs to the extractant agent had a selective effect on the extraction of catechin and epicatechin. The yield of catechin and epicatechin by using aqueous solutions of CDs was similar to that obtained using organic solvents as ethanol.

Conocimientos sobre violencia de género de la población que consulta en Atención Primaria / Knowledge of gender-based violence in the population seen in Primary Care

Objetivo: Determinar conocimientos y actitudes hacia la violencia de género de la población consultante en Atención Primaria y su relación con factores sociodemográficos y experiencias personales.DiseñoEstudio descriptivo transversal.EmplazamientoCentros de Salud urbanos.ParticipantesPacientes ≥ 18 años que acuden a consulta de Atención Primaria.Mediciones principalesSe utilizó un cuestionario que incluía preguntas relativas a conocimientos, actitudes y experiencias vividas en relación con la violencia de género y en el ámbito doméstico, y que también recogía edad, sexo, nivel de estudios, estado civil y detección de experiencias personales de violencia de género mediante la versión corta del Woman Abuse Screening Tool (WAST).ResultadosRespondieron 673 personas, de 18-86 años, con un 68% de mujeres. Solo un 18,2% tenía un adecuado conocimiento sobre quién se considera que ejerce la violencia de género. La mitad de los participantes consideraban que la violencia de género incluía lesiones físicas, psicológicas, cohibición de libertad y violación. A través de un análisis de regresión logística se encontró una asociación independiente con el conocimiento de la respuesta correcta sobre qué es la violencia de género del estado civil, siendo menos probable en los casados con respecto a los viudos (OR: 0,28; IC 95%: 0,11-0,72) considerar que la violencia de género implica lesión física (OR: 2,55; IC 95%: 1,28-5,08), pero no lesiones psicológicas (OR: 0,52; IC 95%: 0,28-0,96), y no dar la respuesta correcta sobre qué es la violencia doméstica (OR: 0,06; IC 95%: 0,03-0,12).ConclusionesExiste una gran dispersión en las respuestas con relación a qué consideran los pacientes que es la violencia de género y qué aspectos abarca(AU)

Objective: To determine the knowledge and attitudes towards gender-based violence in the Primary Care patient population and their relationship with sociodemographic factors and personal experience.DesignA descriptive, cross-sectional study.SettingUrban Health Centres.ParticipantsPatients ≥18 years-old who were seen in a Primary Care clinic.Materials and methodA questionnaire was used that included questions associated with knowledge, attitudes and experience of gender-based violence in the domestic environment. Variables such as, age, sex, education level, marital state were recorded, as well as the detection of personal experiences of Gender-Based Violence using the short Woman Abuse Screening Tool (WAST).ResultsA total of 673 people, from 18- 86 years, responded, of which 68% were women. Only 18.2% had sufficient knowledge on who is considered to exercise gender-based violence. Half of the participants believed that gender-based violence included physical and psychological injuries, inhibition of freedom and rape. In the logistic regression analysis an independent relationship was found with the knowledge of the correct response on what is gender-based violence by marital state, being less likely in married people as regards widowers (OR: 0.28; CI 95%: 0.11-0.72), to consider that gender-based violence involves physical injury (OR: 2.55; CI 95%: 1.28-5.08), but not psychological injury (OR: 0.52; CI 95%: 0.28-0.96), and not giving the correct response on what is domestic violence (OR:0.06; CI 95%: 0.03-0.12).ConclusionsThere is a wide variation in the results as regards what patients believe gender-based violence is and what aspects it covers(AU)

[Knowledge of gender-based violence in the population seen in primary care]. / Conocimientos sobre violencia de género de la población que consulta en Atención Primaria.

OBJECTIVE: To determine the knowledge and attitudes towards gender-based violence in the Primary Care patient population and their relationship with sociodemographic factors and personal experience. DESIGN: A descriptive, cross-sectional study. SETTING: Urban Health Centres. PARTICIPANTS: Patients ≥18 years-old who were seen in a Primary Care clinic. MATERIALS AND METHOD: A questionnaire was used that included questions associated with knowledge, attitudes and experience of gender-based violence in the domestic environment. Variables such as, age, sex, education level, marital state were recorded, as well as the detection of personal experiences of Gender-Based Violence using the short Woman Abuse Screening Tool (WAST). RESULTS: A total of 673 people, from 18-86 years, responded, of which 68% were women. Only 18.2% had sufficient knowledge on who is considered to exercise gender-based violence. Half of the participants believed that gender-based violence included physical and psychological injuries, inhibition of freedom and rape. In the logistic regression analysis an independent relationship was found with the knowledge of the correct response on what is gender-based violence by marital state, being less likely in married people as regards widowers (OR: 0.28; CI 95%: 0.11-0.72), to consider that gender-based violence involves physical injury (OR: 2.55; CI 95%: 1.28-5.08), but not psychological injury (OR: 0.52; CI 95%: 0.28-0.96), and not giving the correct response on what is domestic violence (OR:0.06; CI 95%: 0.03-0.12). CONCLUSIONS: There is a wide variation in the results as regards what patients believe gender-based violence is and what aspects it covers.

Experiencias en relación con la Violencia de Género de la población que consulta en Atención Primaria / Experience in gender violence in the general population within the Primary Care setting

Objetivo. Conocer la prevalencia de violencia de género padecida por la población consultante en Atención Primaria y su relación con factores sociodemográficos y otras experiencias personales. Diseño. Estudio observacional, descriptivo, transversal. Emplazamiento. Centros de Salud urbanos. Participantes. Pacientes de 18 o más años que acuden a consulta de Atención Primaria. Mediciones principales. Se utilizó un cuestionario diseñado ad hoc, que incluía preguntas relativas a las experiencias vividas en relación con la violencia de género y en el ámbito doméstico, junto a la versión corta del Woman Abuse Screening Tool (WAST). También recogía edad, sexo, nivel de estudios y estado civil, así como conocimientos y actitudes con respecto a este tema. Resultados. Respondieron al cuestionario 673 personas. De las 662 personas que respondieron a la pregunta sobre si ha sufrido algún tipo de violencia en sus relaciones sentimentales, 76 dieron una respuesta afirmativa (11,48%; IC 95%: 8,98-13,98%). Esta respuesta era más probable encontrarla en viudos y separados (p<0,00001), mientras que entre los más jóvenes predominaba el no haber sufrido violencia (p=0,01), sin diferencias para otras variables sociodemográficas. Mediante regresión logística, la edad fue la única variable asociada independiente con haber sufrido violencia de género (OR: 1,02; IC95%: 1,005-1,036). Para el test WAST se obtuvieron 560 respuestas, de las que un 12,0 % (IC95%: 9,2-14,7%) fueron positivas. La concordancia entre la respuesta a la pregunta sobre si ha sufrido algún tipo de violencia en sus relaciones sentimentales y el resultado del WAST fue muy baja (Kappa: 0,153; IC 95%: 0,038-0,243). A la pregunta “¿qué ha hecho?” (en caso de violencia en alguna relación sentimental), la respuesta más frecuente es alejarse del agresor. Hasta un 42,1% de los participantes decía conocer a alguna persona que hubiera padecido violencia de género. Conclusiones. Existe un contacto frecuente de las personas que acuden a consulta de atención primaria con la violencia de género, siendo considerable el número de personas que afirman haber sufrido maltrato (AU)

Objectives. To determine the prevalence of gender violence in the general population in the primary care setting and its association with sociodemographic factors and other personal experience. Design. Cross-sectional, observational, descriptive study. Setting. Urban primary care centres. Participants. Patients aged 18 years or over who attended the Primary Care centre. Main measurements. An ad hoc designed questionnaire that included questions on experience of domestic violence and the short version of the Woman Abuse Screening Tool (WAST), were used. Sociodemographic variables and knowledge and attitudes towards gender violence were also collected. Results: A total of 673 persons responded to the questionnaires. Of the 662 subjects who answered the question on whether they had suffered any type of abuse by their partner, 75 answered affirmatively (11.48%; 95% CI: 8.98-13.98%). This response was more probable in widowed or separated subjects (p<0.00001). Amongst young people there was a predominance of not having suffered abuse (p=0.01). There were no differences regarding the other sociodemographic variables. Logistic regression analysis revealed that age was the only variable that demonstrated an independent association with having suffered gender violence (OR: 1.02; 95% CI: 1.005 – 1.036). A total of 560 responses were obtained in the WAST questionnaire and 12.0% were positive (95% CI; 9.2 – 14.7%). Its concordance with the question on history of domestic violence was very low (Kappa: 0.153; 95% CI: 0.038-0.243). In the case of previous abuse, in answer to the question “What did you do? the most frequent response was to get away from the aggressor. Up to 42.1% said they knew someone who was a victim of gender violence. Conclusions. In the primary care setting there is frequent contact with persons suffering gender violence. There are a considerable number of persons who admit to being abused (AU)