ABSTRACT
A large number of studies have been conducted in patients affected by epithelial ovarian cancer to assess the potential utility of a variety of different regimens in patients who have relapsed after primary surgery and adjuvant chemotherapy. In this open prospective study, 32 patients with ovarian cancer of epithelial histology who had relapsed after platinum-based line chemotherapy and had exhausted all standard treatments, received Leuprolide acetate depot 3.75 mg, intramuscularly once a month until tumor progression. Four patients (12.5%) had clinical and/or radiological partial response; remission was then maintained for a mean duration of 8.7 months (range 6-11 months) before new progression occurred. Five patients (15.6%) remained stable for a mean time of 5.2 months (range 4-6 months) and 23 patients (71.9%) continued to progress following therapy and have since died by tumor with a median survival of 3.6 months after initiation of the protocol. Treatment is well-tolerated and no toxicity has been noted. These data stress the significant activity of Leuprolide acetate as a salvage therapy in patients with relapsed advanced epithelial ovarian cancer after previous platinum-based chemotherapies.
Subject(s)
Antineoplastic Agents, Hormonal/therapeutic use , Leuprolide/therapeutic use , Neoplasm Recurrence, Local/drug therapy , Ovarian Neoplasms/drug therapy , Salvage Therapy , Adult , Aged , Female , Humans , Middle Aged , Platinum Compounds/therapeutic use , Prospective Studies , Remission Induction , Survival Rate , Treatment FailureABSTRACT
We report three cases of cervical pregnancy, managed by transabdominal uterine cerclage and cervical curettage: each one was followed by a successful pregnancy. A review of the literature is presented.
Subject(s)
Pregnancy, Ectopic/surgery , Suture Techniques , Ultrasonography, Prenatal , Adult , Cervix Uteri , Female , Follow-Up Studies , Hematoma/diagnostic imaging , Hematoma/surgery , Humans , Infant, Newborn , Male , Postoperative Complications/prevention & control , Pregnancy , Pregnancy, Ectopic/diagnostic imaging , Uterine Cervical Incompetence/prevention & control , Uterine Hemorrhage/diagnostic imaging , Uterine Hemorrhage/surgeryABSTRACT
We report a case of a 43 year old woman who developed an extensive vulvar kerion caused by Trichophyton menthagrophytes that was initially mistaken for a bacterial infection. The peculiarity of this case lies in the fact that the kerion is rarely located in the vulva and it has not yet been described in the literature. On the contrary, cases have been found in the scalp, beard, eye-brow, etc. We discuss the etiopathogenetic aspects, criteria for differential diagnosis and therapy management of this rare clinical picture.
