One-Step Hydrothermal Synthesis of Sn-Doped Sb2Se3 for Solar Hydrogen Production.

Antimony selenide (Sb2Se3) has recently been intensively investigated and has achieved significant advancement in photoelectrochemical (PEC) water splitting. In this work, a facile one-step hydrothermal method for the preparation of Sn-doped Sb2Se3 photocathodes with improved PEC performance was investigated. We present an in-depth study of the performance enhancement in Sn-doped Sb2Se3 photocathodes using capacitance-voltage (CV), drive-level capacitance profiling (DLCP), and electrochemical impedance spectroscopy (EIS) techniques. The incorporation of Sn2+ into the Sb2Se3 results in increased carrier density, reduced surface defects, and improved charge separation, thereby leading to improved PEC performance. With a thin Sb2Se3 absorber layer (270 nm thickness), the Sn-doped Sb2Se3 photocathode exhibits an improved photocurrent density of 17.1 mA cm-2 at 0 V versus RHE (V RHE) compared to that of the undoped Sb2Se3 photocathode (14.4 mA cm-2). This work not only highlights the positive influence of Sn doping on Sb2Se3 photocathodes but also showcases a one-step method to synthesize doped Sb2Se3 with improved optoelectronic properties.

Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-ß aggregation.

Dysregulated metal ions are hypothesized to play a role in the aggregation of the amyloid-ß (Aß) peptide, leading to Alzheimer's disease (AD) pathology. In addition to direct effects on Aß aggregation, both Cu and Fe can catalyze the generation of reactive oxygen species (ROS), possibly contributing to significant neuronal toxicity. Therefore, disruption of metal-Aß interactions has become a viable strategy for AD therapeutic development. Herein, we report a new series of dual-function triazole-pyridine ligands [4-(2-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)ethyl)morpholine (L1), 3-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)propan-1-ol (L2), 2-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)acetic acid (L3), and 5-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)pentan-1-amine (L4)] that interact with the Aß peptide and modulate its aggregation in vitro. Metal chelation and Aß interaction properties of these molecules were studied by UV-vis, NMR spectroscopy and X-ray crystallography. In addition, turbidity and transmission electron microscopy (TEM) were employed to determine the anti-aggregation properties of L1-L4. All compounds demonstrated an ability to limit metal-induced Aß aggregation. Overall, our studies suggest the utility of the triazole-pyridine framework in the development of chemical reagents toward inhibitors for metal-triggered Aß aggregation.