ABSTRACT
Full-thickness macular hole (FTMH) formation in Polypoidal choroidal vasculopathy (PCV) after intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment is a rare complication. Spontaneous closure of FTMH following anti-VEGF therapy has not been described in PCV till date. We present a case of Asian woman with PCV who developed a FTMH following treatment with intra-vitreal anti-VEGF injections which subsequently closed spontaneously on further course of treatment.
Subject(s)
Bevacizumab/administration & dosage , Choroid Diseases/drug therapy , Choroid/blood supply , Polyps/drug therapy , Retinal Perforations/diagnosis , Angiogenesis Inhibitors/administration & dosage , Choroid Diseases/complications , Choroid Diseases/diagnosis , Female , Fluorescein Angiography , Fundus Oculi , Humans , Intravitreal Injections , Middle Aged , Polyps/complications , Polyps/diagnosis , Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors , Remission, Spontaneous , Retinal Perforations/etiology , Tomography, Optical CoherenceABSTRACT
We report the imaging characteristics of focal choroidal excavation (FCE) and associated choroidal neovascular membrane (CNVM) and interpret the probable etiopathogenesis of FCE through findings in four patients detected by spectral-domain optical coherence tomography (SD-OCT). FCE was found as an acquired entity in two of our cases subsequent to treatment of CNVM, whereas in the two other cases FCE was pre-existing. Furthermore, association of FCE with pachychoroid spectrum is reaffirmed through this case series.
