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Am J Gastroenterol ; 113(11): 1639-1648, 2018 11.
Article in English | MEDLINE | ID: mdl-29946175

ABSTRACT

OBJECTIVES: Prisons are major reservoirs of hepatitis C virus (HCV) in which a therapeutic approach has been particularly difficult so far. Our aim was to create a permanent program of HCV elimination in a prison based on a "test and treat" strategy. METHODS: This open-label clinical trial was conducted in the Spanish prison "El Dueso" between May 2016 and July 2017. Viremic patients were treated with a ledipasvir-sofosbuvir regimen (8-12 weeks) according to the 2015 Spanish Guidelines. A teleconsultation program was established to follow-up patients from the hospital. Non-responders were submitted for a phylogenetic analysis and offered retreatment. An evaluation of new cases of HCV infection was performed every 6 months and upon release in all inmates. RESULTS: 847 (99.5%) inmates accepted to participate. HCV antibodies were present in 110 (13.0%) and 86 (10.2%) had detectable viremia. Most of them were genotype 1 or 3 (82.6%) and had

Subject(s)
Antiviral Agents/therapeutic use , Benzimidazoles/administration & dosage , Disease Eradication/trends , Environmental Exposure/adverse effects , Fluorenes/administration & dosage , Hepatitis C, Chronic/prevention & control , Prisons , Uridine Monophosphate/analogs & derivatives , Adult , Aged , Disease Eradication/methods , Disease Eradication/standards , Female , Follow-Up Studies , Hepacivirus/drug effects , Hepacivirus/isolation & purification , Hepatitis C Antibodies/isolation & purification , Hepatitis C, Chronic/blood , Hepatitis C, Chronic/transmission , Hepatitis C, Chronic/virology , Humans , Male , Middle Aged , Practice Guidelines as Topic , Prisoners , Program Evaluation , Sofosbuvir , Spain , Sustained Virologic Response , Uridine Monophosphate/administration & dosage , Viral Load , Viremia/diagnosis , Viremia/drug therapy , Viremia/virology , Young Adult
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