ABSTRACT
A 79-year-old woman presented with vomiting after being prescribed amenamevir by her primary care physician. She had a medical history of rheumatoid arthritis and was administered prednisolone and methotrexate. She was finally diagnosed with herpes zoster ophthalmicus and aseptic meningitis, and intravenous antiviral therapy was initiated. However, the patient developed oculomotor nerve palsy on the 11th day of hospitalization. In this case, there was a time lag between the administration of antiviral drugs and clinical improvement. Our case suggests the necessity of selecting antivirals, especially in high-risk cases of CNS complications, to avoid the low intracerebral transferability of antiviral drugs, including amenamevir.
Subject(s)
Herpes Zoster Ophthalmicus , Herpes Zoster , Meningitis, Aseptic , Oculomotor Nerve Diseases , Humans , Female , Aged , Herpes Zoster Ophthalmicus/complications , Herpes Zoster Ophthalmicus/drug therapy , Herpes Zoster Ophthalmicus/diagnosis , Immunosuppressive Agents/adverse effects , Meningitis, Aseptic/drug therapy , Meningitis, Aseptic/complications , Antiviral Agents/therapeutic use , Oculomotor Nerve Diseases/complications , Oculomotor Nerve Diseases/drug therapy , Herpes Zoster/complications , Herpes Zoster/drug therapyABSTRACT
In this multicenter, matched case-control study, patients diagnosed with catheter-related bloodstream infection (CRBSI) caused by Bacillus cereus (n = 108) were matched to controls (n = 269). In the multivariable analysis, administration of an amino acid preparation and an indwelling peripheral catheter were significant variables for B cereus-related CRBSI.
