1.
Urologiia
; (2): 26-9, 2008.
Article
in Russian
| MEDLINE
| ID: mdl-18572765
ABSTRACT
The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
Subject(s)
Glutathione S-Transferase pi/genetics , Glutathione Transferase/genetics , Mutation , Neoplasm Proteins/genetics , Polymorphism, Genetic , Prostatic Neoplasms/genetics , Aged , Aged, 80 and over , Genotype , Glutathione S-Transferase pi/metabolism , Glutathione Transferase/metabolism , Humans , Male , Middle Aged , Neoplasm Proteins/metabolism , Prostatic Neoplasms/enzymology
2.
Vopr Pitan
; (2): 70, 1982.
Article
in Russian
| MEDLINE
| ID: mdl-6283738