ABSTRACT
Activity of liminal and membrane enzymes and morphologic state of small intestinal mucosa were studied in experimental acute occlusive ileus in rats. It was established that degenerative alterations of intestinal mucosa epithelium above the site of obstruction are more pronounced than in the distal part. The activity of membrane enzymes (invertase) remained unaltered during 72 hours after the obturation, however, serious morphologic damage of the intestinal mucosa epithelium and sharp suppression of the liminal digestion were observed.
Subject(s)
Intestinal Obstruction/pathology , Intestine, Small/pathology , Acute Disease , Animals , Digestion/physiology , Disease Models, Animal , Glycoside Hydrolases/metabolism , Hydrolysis , Intestinal Obstruction/enzymology , Intestinal Obstruction/physiopathology , Intestine, Small/enzymology , Intestine, Small/physiopathology , Male , Rats , Rats, Wistar , beta-FructofuranosidaseABSTRACT
The results of the experiments on 159 Wistar rats have shown that one two-hour session of hyperbaric oxygenation (HBO) under the pressure of 3 ata affects considerably the course of acute respiratory insufficiency syndrome: the mortality rate decreases markedly, the development of arterial hypoxemia and structural changes peculiar to the "wet" lung could be averted. The results of the investigations demonstrate the possibility of HBO application for the prophylaxis and treatment of the syndrome.