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Study of the Association of Polymorphisms of p53 and p21 with the Risk of Development of Stomach Cancer.

Dmitrieva, A I; Serebryakova, V A; Rakitin, S S; Kudyakov, L A; Novitskii, V V; Yankovich, K I; Sevostyanova, N V.

Bull Exp Biol Med ; 164(1): 95-98, 2017 Nov.

Article in English | MEDLINE | ID: mdl-29124536

ABSTRACT

A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.

Subject(s)

Cyclin-Dependent Kinase Inhibitor p21/genetics , Stomach Neoplasms/genetics , Tumor Suppressor Protein p53/genetics , Aged , Case-Control Studies , Female , Gene Frequency , Genetic Association Studies , Genetic Predisposition to Disease , Humans , Male , Middle Aged , Polymorphism, Single Nucleotide , Risk Factors

ABSTRACT

Subject(s)

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