ABSTRACT
Medically unexplained symptoms are considered 'somatoform disorders' in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). The introduction of this nosographic category has been helpful in drawing attention to a previously neglected area, but has not been successful in promoting an understanding of the disorders' biological basis and treatment implications, probably because of a series of diagnostic shortcomings. The newly proposed DSM-V diagnostic criteria try to overcome the limitations of the DSM-IV definition, which was organised centrally around the concept of medically unexplained symptoms, by emphasising the extent to which a patient's thoughts, feelings and behaviours concerning their somatic symptoms are disproportionate or excessive. This change is supported by a growing body of evidence showing that psychological and behavioural features play a major role in causing patient disability and maintaining high level of health care use. Pain disorders is the sub-category of DSM-IV somatoform disorders that most closely resembles fibromyalgia. Regardless of the diagnostic changes recently brought about by DSM-V, neuroimaging studies have identified important components of the mental processes associated with a DSM- IV diagnosis of pain disorder.
Subject(s)
Chronic Pain/etiology , Diagnostic and Statistical Manual of Mental Disorders , Fibromyalgia/diagnosis , Musculoskeletal Pain/etiology , Pain Perception , Rheumatic Diseases/psychology , Somatoform Disorders/diagnosis , Chronic Pain/diagnosis , Chronic Pain/psychology , Diagnosis, Differential , Fibromyalgia/complications , Fibromyalgia/psychology , Humans , Hyperalgesia/diagnosis , Hyperalgesia/etiology , Hyperalgesia/psychology , Musculoskeletal Pain/diagnosis , Musculoskeletal Pain/psychology , Neuroimaging , Pain Measurement , Rheumatic Diseases/complications , Rheumatic Diseases/diagnosis , Somatoform Disorders/classification , Somatoform Disorders/etiology , Somatoform Disorders/psychology , Symptom AssessmentABSTRACT
OBJECTIVES: To review the literature addressing the relationship between mood disorders and fibromyalgia/chronic pain and our current understanding of overlapping pathophysiological processes and pain and depression circuitry. METHODS: We selectively reviewed articles on the co-occurrence of mood disorders and fibromyalgia/chronic pain published between 1990 and July 2012 in PubMed. Bibliographies and cross references were considered and included when appropriate. RESULTS: Forty-nine out of 138 publications were retained for review. The vast majority of the studies found an association between depression and fibromyalgia. There is evidence that depression is often accompanied by symptoms of opposite polarity characterised by heights of mood, thinking and behaviour that have a considerable impact on pharmacological treatment. Recent developments support the view that the high rates of fibromyalgia and mood disorder comorbidity is generated by largely overlapping pathophysiological processes in the brain, that provide a neurobiological basis for the bidirectional, mutually exacerbating and disabling relationship between pain and depression. CONCLUSIONS: The finding of comparable pathophysiological characteristics of pain and depression provides a framework for understanding the relationship between the two conditions and sheds some light on neurobiological and therapeutic aspects.
