ABSTRACT
In a randomized clinical trial the effect of Sodium Valproate in pediatric migraine prophylaxis was compared with that of Propranolol. One hundred and twenty patients with common migraine (migraine without aura) aged from 3 to 15 years who met the defined criteria enrolled into the study. Randomly the patients were divided in two groups of A and B, treating with sodium Valproate and Propranolol, respectively. Three phases of baseline period (phase I), titration and adjustment period (phases II) and fixed -dose treatment period (phase III) have been designed. A total of 57 patients in group A, and 58 patients in group B completed all phases of the trial. Seventy two percent of patients in group A and 69% of patients in group B have responded to Sodium Valproate and Propranolol, respectively, as a reduction of more than 50% in headache frequency per month. Further more both drugs have shown efficacy in reducing the severity and duration of headache and also better response to rescue medications (p value <0.01). There was no significant difference in all previously mentioned therapeutic effects between two groups (p value <0.05).
Subject(s)
Adrenergic beta-Antagonists/therapeutic use , Anticonvulsants/therapeutic use , Migraine Disorders/prevention & control , Propranolol/therapeutic use , Valproic Acid/therapeutic use , Adolescent , Child , Child, Preschool , Humans , Incidence , Migraine Disorders/epidemiology , Migraine Disorders/physiopathology , Severity of Illness Index , Time Factors , Treatment OutcomeABSTRACT
To obtain blood pressure distribution for Iranian children, we assessed 10,288 students aged 6-13 years (4871 boys and 5417 girls) in Tehran. Mean systolic and diastolic blood pressure showed incremental increases with age, weight and height in both sexes. Mean increases in systolic blood pressure for boys and girls were 1.7 and 0.8 mmHg per year respectively and for diastolic blood pressure were 0.7 and 0.9 mmHg respectively. According to Second Task Force (STF) criteria, 4.9% of boys and 3.5% of girls had significant systolic hypertension and 10.1% of boys and 3.3% of girls had significant diastolic hypertension. Mean systolic and diastolic blood pressures were higher than STF reports, especially among boys.
Subject(s)
Hypertension/epidemiology , Students/statistics & numerical data , Adolescent , Age Distribution , Age Factors , Blood Pressure , Body Height , Body Weight , Child , Diastole , Female , Health Surveys , Humans , Hypertension/diagnosis , Hypertension/prevention & control , Iran/epidemiology , Male , Population Surveillance , Prevalence , Reference Values , Severity of Illness Index , Sex Characteristics , Sex Distribution , Systole , Urban Health/statistics & numerical dataABSTRACT
To obtain blood pressure distribution for Iranian children, we assessed 10,288 students aged 6-13 years [4871 boys and 5417 girls] in Tehran. Mean systolic and diastolic blood pressure showed incremental increases with age, weight and height in both sexes. Mean increases in systolic blood pressure for boys and girls were 1.7 and 0.8 mmHg per year respectively and for diastolic blood pressure were 0.7 and 0.9 mmHg respectively. According to Second Task Force [STF] criteria, 4.9% of boys and 3.5% of girls had significant systolic hypertension and 10.1% of boys and 3.3% of girls had significant diastolic hypertension. Mean systolic and diastolic blood pressures were higher than STF reports, especially among boys
