A two-piece dental implant comprising a replaceable thin titanium sleeve may be a new approach to re-osseointegration following peri-implant disease.

Bacteria initiated peri-implantitis can lead to bone destruction around a dental implant, modifying its surface and preventing re-osseointegration. Consequently, all available methods for treating periimplantitis have disappointing long-term results. Implant failure will lead to loss of the prosthetic reconstruction as well. A fresh new implant surface enables re-osseointegration. Our hypothesis is that a fresh new surface replacing a contaminated implant surface may be a new treatment approach for peri-implantitis and may allow re-osseointegration. A new two-piece dental implant, having a replaceable thin titanium sleeve may be designed. The replacement of a contaminated sleeve by a fresh new sleeve will solve the peri-implant disease by removing the contaminated surface, enabling re-osseointegration and ensuring long-term stability of the implant without endangering the prosthetic reconstruction. This minimally-invasive therapy is expected to be conducted in a simple manner, by every practicing dentist, during supportive periodontal treatment, thereby facilitating the treatment of peri-implantitis.

Trauma as a Cause for Hepatopathy in Newborn Göttingen Minipigs.

Routine husbandry procedures during animal toxicity studies can result in incidental pathological changes. We report on trauma-induced hepatopathy in newborn Göttingen minipigs. Sixty-four neonatal minipigs were allocated to 13- and 26-week treatment arms. There was a 4-week recovery period for both arms. The animals were divided into 2 treatment groups and a vehicle group and were dosed 3 times daily by direct oral administration using a syringe. During the feeding procedure in the first weeks, the animals had to be handled firmly. After 13 weeks, randomly distributed foci of degeneration/necrosis and focal congestion and/or hemorrhage were found in the livers of several animals from all groups. Reduced incidence and severity were evident in the recovery phase, and the lesions were absent after 26 weeks. These changes were considered as related to the manual handling of the animals. Knowledge of these findings is crucial for interpretation of studies utilizing newborn minipigs.