ABSTRACT
We studied the levels of ionized calcium in the blood serum of patients with laryngeal cancer (LC) before and after radiotherapy. The levels were measured on the analyzer ICA-1 by ionoselective electrode. LC patients were found to have high pretreatment levels of ionized calcium in all LC locations. After radiotherapy these levels fell also in all locations, especially in the vocal part of the larynx. Thus, radiotherapy can be recommended as an independent treatment method in laryngeal cancer, especially in involvement of vocal part of the larynx. LC treatment efficacy can be assessed by comparing levels of ionized calcium before and after treatment.
Subject(s)
Calcium/metabolism , Laryngeal Neoplasms/metabolism , Laryngeal Neoplasms/radiotherapy , Adult , Aged , Humans , Male , Middle Aged , Time FactorsABSTRACT
Measurements of parathyroid hormone concentrations were made in the serum of patients with vestibular larynx before treatment, after radiation treatment and after radiation treatment followed by surgery. Patients with laryngeal cancer were found to have impaired calcium metabolism, their serum parathyroid hormone concentrations were elevated. After radiotherapy, in a favorable clinical course, patients with cancer of the vestibular larynx stage II show normalization of the hormone levels, whereas the above combined treatment diminished the concentrations, but they still remain above normal.
Subject(s)
Hypopharyngeal Neoplasms/blood , Parathyroid Hormone/blood , Adult , Aged , Calcium/metabolism , Humans , Hypopharyngeal Neoplasms/complications , Male , Middle AgedABSTRACT
Radioimmunoassay was employed to investigate time course changes in blood serum aldosteron in 28 patients with cancer of the middle laryngeal part before and after radiation treatment as well as after radiation treatment followed by surgical intervention. Initial values of aldosteron were low evidencing impaired mineral-corticoid activity of the adrenal cortex. Aldosteron returned to normal after effective radiotherapy at early tumor stage and after radical surgical treatment at later cancer stages. Hormonal unbalance provides more significant information on tumor involvement of the larynx and is a good indicator of the treatment efficiency.
Subject(s)
Adrenal Cortex Diseases/blood , Aldosterone/blood , Laryngeal Neoplasms/therapy , Adrenal Cortex Diseases/complications , Adrenal Cortex Diseases/diagnosis , Adult , Aged , Combined Modality Therapy , Humans , Laryngeal Neoplasms/complications , Male , Middle Aged , Neoplasm Staging , Postoperative PeriodABSTRACT
Plastic reconstruction of the tympanic membrane was performed with the use of tragus perichondrium and cartilage, temporal fascia in 245 and 141 patients, respectively, Tympanoplastic use of the tragus perichondrium and cartilage provides good morphological and functional results. Such surgery may be a method of choice in filling defects of the tympanic membrane.
Subject(s)
Cartilage/surgery , Fasciotomy , Temporal Muscle/surgery , Tympanic Membrane/surgery , Tympanoplasty , Adolescent , Adult , Female , Humans , Male , Middle AgedABSTRACT
Enzyme immunoassay was used to measure serum levels of hydrocortisone and aldosterone in 85 patients with vestibular laryngeal cancer before treatment and after it. The treatment consisted of either radiation alone or radiation followed by surgery. Pretreatment examination revealed adrenal dysfunction evident from enhanced glucocorticoid and inhibited mineral corticoid activity. Radiotherapy alone or in combination with surgery gave rise to a trend to a decline in glucocorticoid activity and stimulated mineral corticoid activity.
Subject(s)
Aldosterone/blood , Aldosterone/radiation effects , Hydrocortisone/blood , Hydrocortisone/radiation effects , Laryngeal Neoplasms/blood , Adrenal Glands/physiopathology , Adrenal Glands/radiation effects , Adult , Aged , Combined Modality Therapy , Humans , Laryngeal Neoplasms/radiotherapy , Laryngeal Neoplasms/surgery , Male , Middle AgedABSTRACT
The paper presents the results obtained at the treatment of middle neck cysts and fistulas. Introduction of the surgical microscope contributed to radical dissection of the fistula passages which prevented the disease recurrences.
