ABSTRACT
Results of a preclinical study of the anxiolytic activity and safety of original Racium phytomedicine are presented. The preparation possessed high anxiolytic activity, exhibits a wide range of therapeutic effects, produces no lethality in male and female rats and mice upon single intragastric and intraperitoneal introduction in doses up to 5 g/kg (VI class of toxicity according to OECD), induces no pathologic effects upon prolonged (120 days) administration in these rodents, and has no local irritant and/or allergen action.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety/drug therapy , Melissa/chemistry , Mentha piperita/chemistry , Phytotherapy , Plant Extracts/therapeutic use , Valerian/chemistry , Animals , Anti-Anxiety Agents/administration & dosage , Anti-Anxiety Agents/chemistry , Anxiety/physiopathology , Anxiety/psychology , Chromatography, High Pressure Liquid , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug-Related Side Effects and Adverse Reactions , Female , Injections, Intraperitoneal , Intubation, Gastrointestinal , Lethal Dose 50 , Male , Mice , Plant Extracts/administration & dosage , Plant Extracts/chemistry , Rats , Sesquiterpenes/analysisABSTRACT
It was shown that the experimental hypofunction of thyroid, induced by thyroidectomy and strong gamma-irradiation with a dose of 1 Gy lead to disturbance of function and structure of membranes of sarcoplasmic reticulum of myocites in rats. Introduction in vivo of L-thyroxine rose functional capacity of membranes with insignificaut changes in their lipid bilayer.
Subject(s)
Hormones/metabolism , Intracellular Membranes/radiation effects , Muscle Cells/radiation effects , Sarcoplasmic Reticulum/radiation effects , Animals , Calcium/metabolism , Dose-Response Relationship, Radiation , Fluorescence , Gamma Rays , Intracellular Membranes/drug effects , Intracellular Membranes/metabolism , Lipid Bilayers/radiation effects , Male , Muscle Cells/drug effects , Muscle Cells/metabolism , Rats , Sarcoplasmic Reticulum/drug effects , Sarcoplasmic Reticulum/metabolism , Thyroid Gland/metabolism , Thyroid Gland/surgery , Thyroidectomy , Thyroxine/pharmacology , Tryptophan/chemistryABSTRACT
It has been found that the combined effect of the acute gamma-irradiation with 1 Gy dose and thyroparathyroidectomy (TPTE) changes the structure-functional state of SR membranes of rat skeletal muscles conditioned by the disturbance of hormonal regulation of molecular-cellular mechanisms of calcium exchange.
