ABSTRACT
The task of this research was to study exogenous insulin effect on blood serum atherogenic potential in patients with type I diabetes mellitus. Under study were relationship between blood serum atherogenic potential in diabetics and daily insulin dose and duration of therapy, as well as exogenous insulin effect on the major atherosclerotic manifestations in tissue cultures, such as intracellular cholesterol content in cultured cells and labeled thymidine incorporation in cellular nuclei DNA. Blood serum atherogenicity did not correlate with insulin dose and duration of insulin therapy both in adult patients and children. Insulin prescription to newly detected patients with type I condition did not influence blood serum atherogenic potential. Exogenic insulin did not influence the major atherosclerotic manifestations at the cellular level, namely, on intracellular cholesterol content in cultured cells and these cells proliferative activity; it had no influence on blood serum atherogenic potential of the patients with type I condition.
Subject(s)
Arteriosclerosis/blood , Diabetes Mellitus, Type 1/blood , Insulin/pharmacology , Adolescent , Adult , Animals , Arteriosclerosis/etiology , Arteriosclerosis/prevention & control , Cell Division/drug effects , Cells, Cultured , Child , Child, Preschool , Cholesterol/metabolism , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/drug therapy , Diabetic Angiopathies/prevention & control , Female , Humans , Male , Mice , Mice, Inbred BALB C , Middle Aged , Thymidine/metabolismABSTRACT
Study of the effects of squid liver fat and krill meat on blood serum atherogenic characteristics in patients with type I diabetes has shown that these foodstuffs had a certain atherogenic effect, for their consumption was associated with a marked reduction of blood serum atherogenicity. The mechanism of this effect is still to be researched.
Subject(s)
Arteriosclerosis/prevention & control , Crustacea , Decapodiformes , Diabetes Mellitus, Type 1/blood , Dietary Fats/pharmacology , Liver , Seafood , Adult , Animals , Arteriosclerosis/diet therapy , Diabetes Mellitus, Type 1/complications , Female , Humans , Male , Middle AgedABSTRACT
Blood serum atherogenicity was studied in children suffering from type I diabetes mellitus, as was the relationship between the serum atherogenicity and a number of clinical biochemical parameters. Of the 34 serum samples from children with diabetes 16 did not influence the intracellular cholesterol levels, the rest 18 were found atherogenic, that is, they increased the total cholesterol levels in the cells by 50-70%. Blood serum atherogenicity in all the examinees and in groups A and B separately was unrelated to the patients' age, insulin dose, fructosamine levels, or the disease standing. A positive correlation was detected between the patients' ages and the insulin dose.
