Persistence and dissipation kinetics of deltamethrin on chili in different agro-climatic zones of India.

Multi-location supervised field trials were conducted at four different agro climatic locations in India to evaluate the dissipation pattern of deltamethrin on chili. Deltamethrin 10 EC was applied on chili @17.5 and 35 g a.i. ha(-1), samples of green chili were drawn at different time intervals and that of red chili and soil at harvest time and quantified by gas liquid chromatography equipped with electron capture detector. The identity of residues were confirmed by Gas Chromatograph-Mass Spectrophotometer in selective ion monitoring mode in mass range 181, 253 m/z. Limit of quantification of the method was found to be 0.01 mg kg(-1). Half-life of deltamethrin at application rate of 17.5 g a.i. ha(-1) varied from 0.36 to 1.99 days and at double the application rate was found to range from 0.38 to 2.06 days. Residues of deltamethrin were found below its determination limit of 0.01 mg kg(-1) in red chili and soil. On the basis of the data generated, Deltamethrin 10 EC has been registered for use on chili in India and its Maximum Residue Limit has been fixed as 0.05 µg/g.

Lack of association among typical congenital hypertrophy of the retinal pigment epithelium, adenomatous polyposis, and Gardner syndrome.

BACKGROUND: It has been recently documented that multiple bilateral pigmented lesions at the level of the retinal pigment epithelium may be an indicator of patients with familial adenomatous polyposis who are prone to develop intestinal cancer, particularly if there is a positive family history of these intestinal disorders. Although atypical, such lesions have been called congenital hypertrophy of the retinal pigment epithelium (CHRPE). This study was undertaken to determine whether the typical lesions of CHRPE, seen frequently by ophthalmologists, also were indicators of familial adenomatous polyposis. METHODS: Review of charts and follow-up studies were performed on all patients diagnosed and coded as having solitary CHRPE or its multifocal variant (congenital grouped pigmentation; bear tracks). Patients and their physicians were contacted by telephone to complete a detailed questionnaire designed to detect signs or symptoms of familial adenomatous polyposis or Gardner syndrome among these patients with CHRPE and their relatives. RESULTS: Of the 132 patients with previously diagnosed CHRPE, there were none with familial adenomatous polyposis, Gardner syndrome, or intestinal cancer, and only one patient had a history of intestinal polyps. Among more than 2000 of their blood relatives, only 20 had intestinal polyposis or colonic cancer (1%). This is much lower than would be expected from a survey of patients with the typical fundus lesions seen with familial adenomatous polyposis. CONCLUSIONS: It appears that solitary CHRPE and congenital grouped pigmentation differ clinically from the multiple pigmented lesions seen with familial adenomatous polyposis and that patients with these conditions, as well as their relatives, are not at a greater risk of developing intestinal cancer.

Band keratopathy secondary to an iris melanoma.

A 27-year-old white man presented with a sectoral band keratopathy overlying an iris melanoma. Clinically, it appeared as a 3 x 3-mm yellowish-white, granular subepithelial deposit in the inferonasal right cornea. Occasional small, round holes were scattered within the opacity. Clinical presentation of this lesion is described, and this unusual cause of band keratopathy is discussed.

Role of adrenals on the 24-hour periodicity in hypothalamo-pituitary axis in male rat.

Studies were carried out to investigate the influence of adrenalectomy on the 24 hour periodicity in the hypothalamo-pituitary axis in adult male rat. Adrenal gland ablation resulted in the shift in the occurrence of peak content of hypothalamic LHRH and attenuation in the responsiveness of the pituitary to synthetic LHRH. Following adrenalectomy, the circadian serum LH peak was attenuated and serum FSH showed a 24 hour periodicity. In conclusion, the results suggest the possible role of adrenal gland in the maintenance of 24 hour periodicity of hormones in the hypothalamo-hypophyseal axis in male rat.

Effect of bromocriptine on gonadal ornithine decarboxylase in vitro.

The alterations in ornithine decarboxylase activity in response to in vitro treatment with bromocriptine suggest the possible direct action of the drug on gonads.

The role of adrenal and pineal glands on the hypothalamo-pituitary axis in adult male rats.

Although there have been reports on the effects of adrenal and pineal gland secretions on the hypothalamus and the pituitary, the maintenance of rhythmicity by these glands has not been reported so far. The present data deals with the alterations in the periodicity of hypothalamo-pituitary axis after the surgical removal of either adrenal, gonad or pineal in adult male rats. The data indicated an alteration in the 24 hour pattern of hypothalamic content of LHRH after adrenalectomy, castration or pinealectomy. In adrenalectomy group, the in vitro responsiveness of pituitary decreased at 0600 h and 100 h as compared to the intact rats, resulting in a low amplitude of LH circadian rhythm. The pituitaries of pinealectomized rats showed increased sensitivity at 1000 h and 1800 h which resulted in two peak LH concentration at those time intervals. Further, pinealectomized rats showed a selective five fold increase over 24 hr in serum FSH concentration as compared to intact rats suggesting dissociation in the release of FSH and LH.

Mode of action of delta-9-tetrahydrocannabinol on hypothalamo-pituitary function in adult female rats.

Administration of delta-9-tetrahydrocannabinol (delta 9-THC) to pro-oestrous rats (5 mg/kg and 10 mg/kg, i.p. for 10 days) decreased the hypothalamic LH-RH content. Serum prolactin levels were reduced but serum LH and FSH and pituitary hormone content were similar to values in dioestrous rats. It is suggested that delta 9-THC acts primarily on the hypothalamus.