ABSTRACT
The efficacy and safety of Mirazid in treatment of human hymenolepiosis were carried out in a rural village in Talkha Center (Dakahlia G.). Kato thick smear stool examination showed 51 cases of Hymenolepis nana (9 of them had concomitant parasitosis), two cases of H. dimninuta. Mirazid was given in a dose of 10 mg/kg/d for nine consecutive days an hour before breakfast for hymenolepiosis cases, as capsule for adults and suppository for children. All cases were subjected to history taking before treatment and six weeks post-treatment and stool examination was repeated as well weekly for six weeks post-treatment. There was overt clinical improvement. Side effects were negligible. Parasitologic cure rate was 40/41 or 95.2% for H. nana one week post-treatment, and 100% for H. diminuta one week post-treatment, up to six weeks follow-up for all treated patients. Two unresponded H. nana patients were cured by another Mirazid course.
Subject(s)
Antiplatyhelmintic Agents/therapeutic use , Commiphora/chemistry , Hymenolepiasis/drug therapy , Hymenolepis/drug effects , Phytotherapy , Plant Extracts/therapeutic use , Adolescent , Adult , Animals , Child , Child, Preschool , Female , Humans , Hymenolepis diminuta/drug effects , Hymenolepis nana/drug effects , Infant , Male , Treatment OutcomeABSTRACT
The encysted metacercariae (EMC) of heterophyids in the fish species; Mugil caphalus, M. capito, M. auratus, Oreochromis n. niloticus (=Tilapia nilotica), and Tilapia zillii trapped brackish and fresh water fishes were isolated by the artificial digestion method and identified. The EMC by morphometric analysis proved to be seven phenotypical distinct types. Cross-matched seven groups of clean laboratory bred puppies each was experimentally infected with a distinct EMC type. The recovered adult flukes were compatible to seven species of six genera of family Heterophyidae. These were Heterophyes heterophyes, H. aequalis, Pygidiopsis genata, Haplorchis yokogawai, Prohemostomumn vivax, Phagicola sp. and Stictodora sp. The EMC of the seven heterophyids were recovered from all the brackish water fishes, M. caphalus, M. capito, M. auratus, O. niloticus and T. zillii. On the other hand, the EMC of P. genata, Haplorchis yokogawai and Phagicola sp. were recovered only from the fresh water fish, O. niloticus and T. zillii. All the EMC was re-described and photographed.
