1.
BMJ Glob Health
; 8(10)2023 10.
Article
in English
| MEDLINE
| ID: mdl-37879652
2.
Chem Biodivers
; 18(10): e2100292, 2021 Oct.
Article
in English
| MEDLINE
| ID: mdl-34467653
ABSTRACT
A series of rationally designed platanic acid-based compounds derived from naturally occurring betulinic acid were synthesized through a sequence of Lemieux-Johnson oxidation and Aldol condensation reaction. All the compounds were screened for cytotoxicity against a panel of human cancer and normal cell lines using MTT assay. From the biological data, it was observed that some of these semi-synthetic congeners exhibited potent biological profiles compared to platanic acid. One of the compounds with the p-tolyl substitution was found to be most active in this study, and its cytotoxicity against two of the cell lines, MDA-MB 231 and A-549 were in tune with the standard compound, 5-fluorouracil.