ABSTRACT
Among the clinical presentation of plasma cell proliferative disorders the extramedullary plasmacytomas are the most infrequent after multiple myeloma and plasma cell tumours of the bones. The plasmacytoma of the thyroid gland to our knowledge has never been reported from Pakistan so far. We present the clinical picture and clinical challenges posed in diagnosis and treatment by this unusual proliferative disorder.
Subject(s)
Plasmacytoma/diagnosis , Plasmacytoma/surgery , Thyroid Neoplasms/diagnosis , Thyroid Neoplasms/surgery , Thyroidectomy/methods , Aged , Biopsy , Diagnosis, Differential , Female , Humans , Plasmacytoma/pathology , Thyroid Neoplasms/pathologyABSTRACT
We present a 15-years old young child primarily presented to general surgeon for abdominal mass and gross haematuria. His detailed imaging studies and other relevant investigations revealed that it is a case of Paediatric Renal Cell carcinoma (RCC), which was clinically not associated with any of the known malignancies or syndromes. On detailed histo-pathological examination this was reported as a special type of Pediatric RCC not fitting into clear cell, papillary, chromophobic, oncocytoma, or collecting duct RCC.
Subject(s)
Carcinoma, Renal Cell/diagnosis , Kidney Neoplasms/diagnosis , Adolescent , Carcinoma, Renal Cell/genetics , Carcinoma, Renal Cell/pathology , Diagnosis, Differential , Diagnostic Imaging , Humans , Kidney Neoplasms/genetics , Kidney Neoplasms/pathology , MaleABSTRACT
Kaposi Sarcoma (KS) is a rare entity. In the north west of Pakistan and Afghanistan, we mostly come across non-HIV related Kaposi sarcoma as Human Immunodeficiency Virus (HIV). Infections are rare in this part of the world. Here, we present a case of a non-auto Immunodeficiency Disease (AIDS) related KS. A 45-year-old male, Afghan patient presented to our oncology outpatient's unit with multiple subcutaneous nodules. The sites of involvement were the periorbital region, retro-auricular region, forearms, legs, chest and back. Oral mucosa was spared at the nodules. The patient had no visceromegaly at the time of presentation. A biopsy specimen from the retro-auricular region revealed a KS with dermal lymphatic involvement. His serum was negative for the common types of viral infections including Human Immunodeficiency Virus (HIV) on routine serology. His total B-lymphocytes (CD 19+), total T-lymphocyte (CD3+), total CD4+ lymphocyte (CD3+, CD4+) and total CD8+ (CD3+, CD8+) counts were all normal or borderline high. The patient was under treatment with 3 weekly chemotherapeutic regimens of Adriamycin, Bleomycin, Vincristine (ABV) keeping in view socioeconomical constrains, logistical difficulties in getting proper medical care and side effects of other options like radiotherapy for extended surface areas.
