ABSTRACT
Extracellular vehicles (EVs) have been involved in several aspects of pregnancy, including endometrial receptivity, embryo implantation, and embryo-maternal communication showing them associated with pregnancy disorders, such as preeclampsia, gestational diabetes mellitus, and preterm birth. Further research is warranted to fully comprehend the exact pathophysiological roles of EVs and to develop new therapies targeting EVs thereby improving pregnancy outcomes. Herein, we review the recent knowledge on the multifaceted roles of EVs during pregnancy and address the majority of the molecular interactions between EVs, maternal, and fetal cells with an emphasis on disorders of pregnancy under the influence of EVs. Moreover, we also discuss its applications in clinical trials followed by prospects.
Subject(s)
Extracellular Vesicles , Humans , Pregnancy , Extracellular Vesicles/metabolism , Female , Animals , Pregnancy Complications/metabolism , Pregnancy Complications/therapy , Embryo Implantation/physiologyABSTRACT
Microplastics (MPs) are biologically active environmental pollutants having significant impact on the ecosystem and human health. MPs have been reported to increase oxidative stress, resulting in tissue damage, developmental abnormalities, metabolic disorders, epigenetic changes, abnormal reproduction, and reduced gamete quality. At present, most of the existing literature has focused on the effects of MPs on the reproduction of various aquatic organisms; however, the effects of MPs on mammalian reproduction specifically humans are least studied except a few ones fragmentally discussing the effects of MPs on gametogenesis in human. This review discusses effects of MPs on male and female reproduction with a focus on different metabolic pathways involved in compromised gamete quality, gamete toxicity, apoptosis, and DNA damage.
Subject(s)
Microplastics , Water Pollutants, Chemical , Female , Humans , Male , Ecosystem , Microplastics/toxicity , Plastics/toxicity , Reproductive Health , Signal Transduction , Water Pollutants, Chemical/toxicity , Water Pollutants, Chemical/analysisABSTRACT
Natural killer (NK) cells are considered to be the foremost fighters of our innate immune system against foreign invaders and thus tend to promptly latch onto the virus-infected and tumor/cancerous cells, killing them through phagocytosis. At present, the application of genetically engineered Chimeric antigen receptor (CAR) receptors ensures a guaranteed optimistic response with NK cells and would not allow the affected cells to dodge or escape unchecked. Hence the specificity and uniqueness of CAR-NK cells over CAR-T therapy make them a better immunotherapeutic choice to reduce the load of trafficking of numerous tumor cells near the healthy cell populations in a more intact way than offered by CAR-T immunotherapy. Our review mainly focuses on the preclinical, clinical, and recent advances in clinical research trials and further strategies to achieve an augmented and efficient cure against solid tumors.
Subject(s)
Neoplasms , Receptors, Chimeric Antigen , Humans , Receptors, Chimeric Antigen/genetics , Killer Cells, Natural , Neoplasms/pathology , Immunotherapy, Adoptive , ImmunotherapyABSTRACT
Cell death is a natural mechanism for biological clearance for the maintenance of homeostasis in a dynamic microenvironment of the central nervous system. Stress and various factors can lead to imbalance between cellular genesis and cell death leading to dysfunctionality and a number of neuropathological disorders. Drug repurposing can help bypass development time and cost. A complete understanding of drug actions and neuroinflammatory pathways can lead to effective control of neurodegenerative disorders. This review covers recent advances in various neuroinflammatory pathways understanding, biomarkers, and drug repurposing for neuroprotection.
Subject(s)
Neurodegenerative Diseases , Neuroprotection , Humans , Neuroinflammatory Diseases , Drug Repositioning , Central Nervous System/metabolism , Neurodegenerative Diseases/drug therapy , Neurodegenerative Diseases/metabolismABSTRACT
Extracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.
